New derivatives of 6-phenylcomanic acid

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• 作者：B. I. Usachev ; D. L. Obydennov ; M. I. Kodess ; G. -V. R?schenthaler and V. Ya. Sosnovskikh
• 关键词：6 ; phenylcomanic acid and its derivatives ; 4 ; hydroxy ; 6 ; phenylpicolinic acid and its derivatives ; phenylhydrazine ; Fischer indole synthesis
• 刊名：Russian Chemical Bulletin
• 出版年：2009
• 出版时间：June, 2009
• 年：2009
• 卷：58
• 期：6
• 页码：1248-1252
• 全文大小：263.5 KB

文摘

Ethyl 6-phenylcomanic acid with hydrazine hydrate and hydroxylamine gives 4-oxo-6-phenyl-4H-pyran-2-carbohydrazide and 4-oxo-6-phenyl-4H-pyran-2-carbohydroxamic acid, whereas 6-phenylcomanic acid with ammonia in aqueous DMSO gives 4-hydroxy-6-phenylpicolinic acid, converted further to its ethyl ester and hydrazide. The reaction of 6-phenylcomanic acid with phenylhydrazine gives rise to 3-(1,5-diphenyl-1H-pyrazol-3-yl)-2-(2-phenylhydrazono)propionic acid, which by the Fischer reaction was converted to 3-(1,5-diphenyl-1H-pyrazol-3-yl)-1H-indole-2-carboxylic acid.