Microvascular ischemia in hypertrophic cardiomyopathy: new insights from high-resolution combined quantification of perfusion and late gadolinium enhancement
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- 作者：Adriana D. M. Villa ; Eva Sammut…
- 关键词：Hypertrophic cardiomyopathy ; Stress test ; Perfusion imaging ; Adenosine ; Late gadolinium enhancement ; Cardiovascular magnetic resonance
- 刊名：Journal of Cardiovascular Magnetic Resonance
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：2,756 KB
- 刊物主题：Imaging / Radiology; Angiology; Cardiology;
- 出版者：BioMed Central
- ISSN：1532-429X
- 卷排序：18
文摘
BackgroundMicrovascular ischemia is one of the hallmarks of hypertrophic cardiomyopathy (HCM) and has been associated with poor outcome. However, myocardial fibrosis, seen on cardiovascular magnetic resonance (CMR) as late gadolinium enhancement (LGE), can be responsible for rest perfusion defects in up to 30 % of patients with HCM, potentially leading to an overestimation of the ischemic burden. We investigated the effect of left ventricle (LV) scar on the total LV ischemic burden using novel high-resolution perfusion analysis techniques in conjunction with LGE quantification.