Identification of cardiomyopathy associated circulating miRNA biomarkers in patients with muscular dystrophy using a complementary cardiovascular magnetic resonance and plasma profiling approach
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- 作者：Svetlana Becker ; Anca Florian…
- 关键词：miRNA ; Cardiomyopathy ; Muscular dystrophy ; Cardiovascular magnetic resonance ; Late gadolinium enhancement
- 刊名：Journal of Cardiovascular Magnetic Resonance
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：2,470 KB
- 刊物主题：Imaging / Radiology; Angiology; Cardiology;
- 出版者：BioMed Central
- ISSN：1532-429X
- 卷排序：18
文摘
BackgroundDuchenne and Becker muscular dystrophy (DMD and BMD) are X-chromosomal recessive neuromuscular disorders that are caused by mutations in the dystrophin gene and characterized by cardiac involvement. Circulating microRNAs (miRNAs) have been proposed as diagnostic biomarkers for various cardiovascular diseases. However, circulating miRNAs reflecting the presence and/or disease severity of cardiac involvement in DMD/BMD patients have not been described so far.