Vitamin D and chronic diseases: the current state of the art
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- 作者：Giovanna Muscogiuri ; Barbara Altieri ; Cedric Annweiler…
- 关键词：Vitamin D ; Musculoskeletal disorders ; Cancer ; Cardiovascular diseases ; Dementia ; Autism ; Diabetes mellitus ; Hypogonadism ; Fertility ; PCOS ; Environment ; Lifestyle ; Endometriosis
- 刊名：Archives of Toxicology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：91
- 期：1
- 页码：97-107
- 全文大小：
- 刊物主题：Pharmacology/Toxicology; Occupational Medicine/Industrial Medicine; Environmental Health; Biomedicine, general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0738
- 卷排序：91
文摘
The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document’s topic that was subjected to voting by all experts as “yes” (agreement with the content and/or wording) or “no” (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with <25 % would be rejected outright. Others would be subjected to further discussion and subsequent voting, where ≥67 % support or, in an eventual third round, a majority of ≥50 % would be needed. This document finds that the current evidence support a role for vitamin D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.