A novel AAT-deletion mutation in the coding sequence of the BCO2 gene in yellow-fat rabbits

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• 作者：Janusz Strychalski ; Pawe? Brym ; Urszula Czarnik…
• 关键词：BCO2 ; Carotenoids ; Deletion mutation ; Rabbits ; Yellow fat
• 刊名：Journal of Applied Genetics
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：56
• 期：4
• 页码：535-537
• 全文大小：238 KB
• 参考文献：Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J (2011) A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J 25:948-59PubMedCentral CrossRef PubMed
  Gugo?ek A, Antoszkiewicz Z, Daszkiewicz T, Cilulko J, (2010) Characteristics of visceral fat in rabbits and pigeons. Proc IV Int Sci Conf., Meat in technology and human nutrition, Poznań-Rosnówko, pp. 81-2.
  Kotake-Nara E, Nagao A (2011) Absorption and metabolism of xantophylls. Mar Drugs 9:1024-037PubMedCentral CrossRef PubMed
  Lietz G, Oxley A, Boesch-Saadatmandi C, Kobayashi D (2012) Importance of β, β-carotene 15,15-monooxygenase 1 (BCMO1) and β, β-carotene 9-10-dioxygenase 2 (BCDO2) in nutrition and health. Mol Nutr Food Res 56:241-50CrossRef PubMed
  Lindqvist A, He Y-G, Andersson S (2005) Cell type-specific expression of β-carotene 9-10-monooxygenase in human tissues. J Histochem Cytochem 53:1403-412CrossRef PubMed
  Moise AR, von Lintig J, Palczewski K (2005) Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. Trends Plant Sci 10:178-86CrossRef PubMed
  Pease M (1930) The inheritance of yellow-fat in rabbits. Verh 1 Internat Kaninchenzuchter Kongresses, Leipzig pp. 91-5.
  Tian R, Pitchford WS, Morris CA, Cullen NG, Bottema CDK (2009) Genetic variation in the β, β-carotene 9- 10-dioxygenase gene and association with fat colour in bovine adipose tissue and milk. Anim Genet 41:253-59CrossRef PubMed
  Tian R, Cullen NG, Morris CA, Fisher PJ, Pitchford WS, Bottema CDK (2012) Major effect of retinal short-chain dehydrogenase reductase (RDHE2) on bovine fat colour. Mamm Genome 23:378-86CrossRef PubMed
  V?ge DI, Boman IA (2010) A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (Ovis aries). BMC Genet 11:10PubMedCentral CrossRef PubMed
  Wilson WK, Dudley FJ (1946) Fat colour and fur colour in different varieties of rabbit. J Genet 47(3):290-94CrossRef PubMed
  
• 作者单位：Janusz Strychalski (1)
  Pawe? Brym (2)
  Urszula Czarnik (2)
  Andrzej Gugo?ek (1)
  
  1. Department of Fur-bearing Animal Breeding and Game Management, University of Warmia and Mazury, Olsztyn, Poland
  2. Department of Animal Genetics, University of Warmia and Mazury, Olsztyn, Poland
  
• 刊物主题：Life Sciences, general; Animal Genetics and Genomics; Human Genetics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：Springer Berlin Heidelberg
• ISSN：2190-3883

文摘

The carcasses of yellow-fat rabbits may be attractive to modern consumers, because they have a relatively high content of biologically active compounds. One of the main candidate genes associated with the yellow-fat trait is β-carotene 9-10-oxygenase (BCO2). This study is the first report of the novel AAT-deletion mutation at codon 248 of the BCO2 gene, which has been found in homozygous yellow-fat rabbits. The deletion mutation, located at the beginning of exon 6, results in the absence of asparagine in protein. We also developed a PCR-RFLP test that supports intravital genotyping of indel polymorphism based on genomic DNA. Keywords BCO2 Carotenoids Deletion mutation Rabbits Yellow fat