The expression of the chemokine receptor CCR5 in tick-borne encephalitis
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- 作者：Sambor Grygorczuk ; Joanna Osada ; Miłosz Parczewski…
- 关键词：Tick ; borne encephalitis ; Th lymphocytes ; Chemokines ; CCR5 ; CCR5Δ32
- 刊名：Journal of Neuroinflammation
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：13
- 期：1
- 全文大小：3,024 KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
文摘
Background Chemokine receptor 5 (CCR5) is hypothesized to drive the lymphocyte migration to central nervous system in flavivirus encephalitis, and the non-functional CCR5Δ32 genetic variant was identified as a risk factor of a West Nile virus infection and of tick-borne encephalitis (TBE). We have attempted to investigate how CCR5 expression corresponds to the clinical course and severity of TBE.