CD80 Is Upregulated in a Mouse Model with Shear Stress-Induced Atherosclerosis and Allows for Evaluating CD80-Targeting PET Tracers
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- 作者：Romana Meletta ; Larissa Steier ; Nicole Borel ; Linjing Mu…
- 关键词：Key wordsPositron emission tomography ; Atherosclerosis ; CD80 ; ApoE KO ; Shear stress ; Plaque inflammation ; [18F]FDG
- 刊名：Molecular Imaging and Biology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：19
- 期：1
- 页码：90-99
- 全文大小：
- 刊物主题：Imaging / Radiology;
- 出版者：Springer US
- ISSN：1860-2002
- 卷排序：19
文摘
PurposeA shear stress-induced atherosclerosis mouse model was characterized for its expression of inflammation markers with focus on CD80. With this model, we evaluated two positron emission tomography (PET) radiotracers targeting CD80 as well as 2-deoxy-2-[18F]fluoro-d-mannose ([18F]FDM) in comparison with 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG).