LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs

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• 作者：Shiori Mori ; Mutsumi Araki ; Shuhei Ishii…
• 关键词：Lysophosphatidic acid ; LPA receptor ; Cell motility ; Endothelial cells ; Anticancer drugs
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：408
• 期：1-2
• 页码：147-154
• 全文大小：965 KB
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• 作者单位：Shiori Mori (1) r> Mutsumi Araki (1) r> Shuhei Ishii (1) r> Miku Hirane (1) r> Kaori Fukushima (1) r> Ayaka Tomimatsu (1) r> Kaede Takahashi (1) r> Nobuyuki Fukushima (2) r> Toshifumi Tsujiuchi (1) r>r>1. Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kinki University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan r> 2. Division of Molecular Neurobiology, Department of Life Science, Faculty of Science and Engineering, Kinki University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan r>
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciencesr>Biochemistryr>Medical Biochemistryr>Oncologyr>Cardiologyr>
• 出版者：Springer Netherlands
• ISSN：1573-4919

文摘

Lysophosphatidic acid (LPA) signaling via LPA receptors provides a variety of cellular functions, including angiogenesis. In this study, to assess an involvement of LPA receptors in cell motile activities of endothelial cells during chemotherapy, F-2 cells were treated with cisplatin (CDDP) and doxorubicin (DOX) at a concentration of 0.01 μM every 24 h for at least 1 month. The treatment of CDDP and DOX inhibited the expression levels of the LPA receptor-1 (Lpar1), Lpar2, and Lpar3 genes in F-2 cells. The cell motile activities of CDDP and DOX treated cells were relatively lower than those of untreated cells. Next, we investigated whether cancer cells could stimulate the cell motile activities of F-2 cells treated with CDDP and DOX. For cell motility assay, CDDP- and DOX-treated cells were co-cultured with pancreatic cancer PANC-1 cells. The cell motile activities of CDDP- and DOX-treated cells were significantly enhanced by the existence of PANC-1 cells, correlating with the LPA receptor expressions. In addition, the elevated cell motile activities were suppressed by the pretreatment of an autotaxin inhibitor S32826. These results suggest that LPA signaling via LPA receptors may regulate the cell motile activities of F-2 cells treated with anticancer drugs. Keywords Lysophosphatidic acid LPA receptor Cell motility Endothelial cells Anticancer drugs