Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway

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• 作者：Hao-Wei Cheng ; Yi-Fang Chen ; Jau-Min Wong…
• 关键词：Endothelial cell ; Lung cancer ; Angiogenesis ; Apoptosis ; PI3K/Akt
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：36
• 期：1
• 全文大小：2719KB
• 刊物主题：Oncology; Cancer Research; Immunology; Apoptosis;
• 出版者：BioMed Central
• ISSN：1756-9966
• 卷排序：36

文摘

BackgroundAngiogenesis is a hallmark of cancer and plays a critical role in lung cancer progression, which involves interactions between cancer cells, endothelial cells and the surrounding microenvironment. However, the gene expression profiles and the changes in the biological phenotype of vascular endothelial cells after interactions with lung cancer cells remain unclear.