Transfer hydrogenation reactions catalyzed by chiral half-sandwich Ruthenium complexes derived from Proline
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- 作者：ARUN KUMAR PANDIA KUMAR ; ASHOKA G SAMUELSON
- 关键词：Asymmetric transfer hydrogenation ; Proline diamine ligands ; Half ; sandwich ruthenium complexes ; Chiral alcohols ; Ruthenium hydride.
- 刊名：Journal of Chemical Sciences
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：128
- 期：9
- 页码：1405-1415
- 全文大小：1,439 KB
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Chemistry - 出版者：Springer India
- ISSN：0973-7103
- 卷排序：128
文摘
Chiral ruthenium half-sandwich complexes were prepared using a chelating diamine made from proline with a phenyl, ethyl, or benzyl group, instead of hydrogen on one of the coordinating arms. Three of these complexes were obtained as single diastereoisomers and their configuration identified by X-ray crystallography. The complexes are recyclable catalysts for the reduction of ketones to chiral alcohols in water. A ruthenium hydride species is identified as the active species by NMR spectroscopy and isotopic labelling experiments. Maximum enantio-selectivity was attained when a phenyl group was directly attached to the primary amine on the diamine ligand derived from proline.