Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing
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- 作者：Eunhui Seo ; Jae Soo Lim ; Jin-Bum Jun ; Woohyuk Choi…
- 关键词：Diabetic wound ; Angiogenesis ; Exendin ; 4 ; GLP ; 1 ; Adipose ; derived stem cells
- 刊名：Journal of Translational Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：1775KB
- 刊物主题：Biomedicine, general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1479-5876
- 卷排序：15
文摘
BackgroundDiminished wound healing is a major complication of diabetes mellitus and can lead to foot ulcers. However, there are limited therapeutic methods to treat this condition. Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, is known to have many beneficial effects on diabetes. In addition, mesenchymal stem cells are known to have wound healing effects. We investigated the effects of Ex-4 in combination with human adipose tissue-derived stem cells (ADSCs) on diabetic wound healing in a diabetic animal model.