Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro
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- 作者：Laura Riccetti ; Francesco De Pascali…
- 关键词：LH ; hCG ; Leydig ; cAMP ; Testosterone ; Bioassay
- 刊名：Reproductive Biology and Endocrinology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：948KB
- 刊物主题：Reproductive Medicine; Endocrinology;
- 出版者：BioMed Central
- ISSN：1477-7827
- 卷排序：15
文摘
BackgroundHuman luteinizing hormone (LH) and chorionic gonadotropin (hCG) are glycoprotein hormones regulating development and reproductive functions by acting on the same receptor (LHCGR). We compared the LH and hCG activity in gonadal cells from male mouse in vitro, i.e. primary Leydig cells, which is a common tool used for gonadotropin bioassay. Murine Leydig cells are naturally expressing the murine LH receptor (mLhr), which binds human LH/hCG.