Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo

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• 作者：Bo-Kai Wu ; Rey-Yue Yuan ; Huang-Wei Lien ; Chin-Chun Hung…
• 关键词：Tauopathy ; Bcl2 ; L1 ; Nrf2 ; Neurotoxicity ; GDNF ; Zebrafish
• 刊名：Journal of Biomedical Science
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：23
• 期：1
• 全文大小：3,101 KB
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• 作者单位：Bo-Kai Wu (1) (2)
  Rey-Yue Yuan (3)
  Huang-Wei Lien (4)
  Chin-Chun Hung (2)
  Pung-Pung Hwang (4)
  Rita Pei-Yeh Chen (2)
  Chun-Che Chang (1) (5)
  Yung-Feng Liao (4)
  Chang-Jen Huang (2)
  
  1. Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan
  2. Institute of Biological Chemistry, Academia Sinica, 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan
  3. Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan
  4. Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan
  5. Department of Entomology, National Taiwan University, Taipei, 106, Taiwan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  
• 出版者：Springer Netherlands
• ISSN：1423-0127

文摘

Background The axonal tau protein is a tubulin-binding protein, which plays important roles in the formation and stability of the microtubule. Mutations in the tau gene are associated with familial forms of frontotemporal dementia with Parkinsonism linked to chromosome-17 (FTDP-17). Paired helical filaments of tau and extracellular plaques containing beta-amyloid are found in the brain of Alzheimer’s disease (AD) patients.