Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells

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• 作者：Jun Ma ; Jun Liu ; Chunwei Lu ; Dingfang Cai
• 关键词：Pachymic acid ; Lung cancer ; Apoptosis ; JNK ; ER stress
• 刊名：Cancer Cell International
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：9,544 KB
• 刊物主题：Cancer Research; Cell Biology;
• 出版者：BioMed Central
• ISSN：1475-2867

文摘

Background Pachymic acid (PA), a lanostane-type triterpenoid from Poria cocos, has been reported to possess anti-emetic, anti-inflammatory, and anti-cancer properties. Nonetheless, the anti-tumor effect of PA in lung cancer cells remains unclear. Herein, we report the chemotherapeutic effects and underlying mechanisms of PA against human lung cancer.