The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance

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• 作者：Luyao Liu ; Zhu-lin Yang ; Chunwei Wang ; Xiongying Miao…
• 刊名：Pathology & Oncology Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：22
• 期：3
• 页码：483-492
• 全文大小：906 KB
• 刊物主题：Cancer Research; Oncology; Pathology; Immunology; Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：1532-2807
• 卷排序：22

文摘

Gallbladder cancers (GBCs) are highly malignant gastrointestinal cancers. The biological makers for the prognosis and targeting therapy of GBCs have not been established. The protein expression of Notch 1 and Notch 3 in 46 squamous cell/adenosquamous carcinomas (SC/ASCs) and 80 adenocarcinomas (AC) was measured using immunohistochemistry. Positive Notch 1 and Notch 3 expression in both SC/ASC and AC was significantly associated with large tumor size, invasion, metastasis, and low surgical curability (P < 0.05 or P < 0.01). Univariate Kaplan-Meier analysis showed that positive Notch 1 and Notch 3 expression was significantly associated with mean survival of SC/ASC and AC patients (P < 0.01 or P < 0.001). Multivariate Cox regression analysis showed that positive Notch 1 and Notch 3 expression, as well as low differentiation, large tumor size, high TNM stage, invasion, lymph node metastasis, and surgical curability are independent poor-prognostic factors in both SC/ASC and AC patients. Positive Notch 1 and Notch 3 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in both SC/ASC and AC patients.KeywordsGallbladder cancerPrognosisNotch 1Notch 3AdenocarcinomaSquamous cell/adenosquamous carcinomas