文摘
Fe3O4/carbon nanotubes (Fe3O4/CNTs) nanocomposites were prepared by polylol high-temperature decomposition of the precursor ferric chloride and CNTs in liquid triethylene glycol. After surface modification with hexanediamine, folate was covalently linked to the amine group of magnetic Fe3O4/CNTs nanocomposites. The products were characterized by Fourier-transform infrared spectroscopy, transmission electron microscopy, and vibrating sample magnetometry. Then Fe3O4/CNTs were used as a dual-drug carrier to co-delivery of the hydrophilic drug epirubicin hydrochloride and hydrophobic drug paclitaxel. The results indicated that the Fe3O4/CNTs had a favorable release property for epirubicin and paclitaxel, and thus had potential application in tumor-targeted combination chemotherapy.