Colonic polyposis syndromes—An experience from a tertiary centre in South India

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• 作者：Sreejesh Sreedharanunni ; Roopa Paulose ; Annie Jojo…
• 关键词：Attenuated familial adenomatous polyposis ; Cronkhite ; Canada syndrome ; Familial adenomatous polyposis ; Hyperplastic polyposis ; Juvenile polyposis syndrome ; Peutz ; Jeghers syndrome
• 刊名：Indian Journal of Gastroenterology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：34
• 期：3
• 页码：233-239
• 全文大小：1,217 KB
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• 作者单位：Sreejesh Sreedharanunni (1)
  Roopa Paulose (1)
  Annie Jojo (1)
  Puneet Dhar (2)
  P. Gangadharan (3)
  
  1. Department of Pathology, Amrita Institute of Medical Sciences, Ponekkara, Kochi, 682 041, India
  2. Department of Gastrointestinal Surgery, Amrita Institute of Medical Sciences, Ponekkara, Kochi, 682 041, India
  3. Department of Cancer Registry, Amrita Institute of Medical Sciences, Ponekkara, Kochi, 682 041, India
  
• 刊物主题：Gastroenterology; Hepatology;
• 出版者：Springer India
• ISSN：0975-0711

文摘

Background Several polyposis syndromes of the gastrointestinal tract have been recognized which carry increased risk for cancer and have a genetic predisposition. There is a paucity of literature regarding the occurrence and the burden of colonic polyposis syndromes in the Indian subcontinent. This study attempts to highlight this hitherto unaddressed burden and the associated increased risk for inherited colonic cancer in this geographical location. Methods A retrospective study of various colonic polyposis syndromes encountered at a tertiary centre in South India over a period of 8?years (2005 to 2012) was performed. The diagnosis in each case was made histologically with clinicopathological correlation. Results Fifty cases were identified as belonging to a colonic polyposis syndrome, during the study period. There were 27 males and 23 females with a median age of 36.5?years (range 19?months to 78?years). The commonest syndrome was familial adenomatous polyposis (n--7; 54?%) followed by Peutz-Jeghers syndrome (n--1), attenuated familial adenomatous polyposis (n--), juvenile polyposis syndrome (n--), hyperplasic polyposis syndrome (n--) and Cronkhite-Canada syndrome (n--). Colonic malignancy was documented at first presentation in 22 patients (44?%). Conclusions Our study highlights the various colonic polyposis syndromes encountered in a tertiary care institution in Southern India.