Association of XRCC1 polymorphisms with arsenic methylation

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• 作者：Junko Fujihara ; Toshihiro Yasuda ; Hisato Iwata ; Shinsuke Tanabe…
• 关键词：X ; ray repair cross ; complementing group 1 (XRCC1) ; Base excision repair (BER) ; Single nucleotide polymorphisms (SNPs) ; 8 ; Hydroxy ; 2′-deoxyguanosine (8 ; OHdG) ; Arsenic compounds
• 刊名：Archives of Toxicology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：90
• 期：4
• 页码：1009-1012
• 全文大小：391 KB
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• 作者单位：Junko Fujihara (1)
  Toshihiro Yasuda (2)
  Hisato Iwata (3)
  Shinsuke Tanabe (3)
  Haruo Takeshita (1)
  
  1. Department of Legal Medicine, Shimane University School of Medicine, Izumo, 693-8501, Japan
  2. Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Fukui, Japan
  3. Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama, 790-8577, Japan
  
• 刊物主题：Pharmacology/Toxicology; Occupational Medicine/Industrial Medicine; Environmental Health; Biomedicine general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0738

文摘

The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in p.Pro206Pro showed significantly higher urinary monomethylarsonic acid (MMAV) and lower dimethylarsinic acid (DMAV)/MMAV ratio than genotype AG. As for p.Arg399Gln, both Arg/Arg homozygous subjects and Arg/Gln heterozygous individuals showed a significantly higher urinary inorganic As percentage and lower 8-OHdG concentrations than Gln/Gln homozygous. Our results suggested that Arg399Gln is a functional SNP that may be related to DNA repair activity.