Do Intron and Coding Sequences of Some Human–Mouse Orthologs Evolve as a Single Unit?

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• 作者：Miguel Angel Fuertes ; José Ramón Rodrigo ; Carlos Alonso
• 刊名：Journal of Molecular Evolution
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：82
• 期：6
• 页码：247-250
• 全文大小：404 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Microbiology
  Plant Sciences
  
• 出版者：Springer New York
• ISSN：1432-1432
• 卷排序：82

文摘

It has been previously suggested that both the coding and the associated non-coding sequences of some human–mouse orthologs could evolve as a single unit. This letter deals with the observation that between mouse and humans some orthologs change significantly their compositional features as an indication that the molecular evolution is a local process. Moreover, the data shown indicate that the coding and the intron sequences of these orthologs do not evolve independently but instead both undergo a concerted evolution, evolving as a single unit, from a compositional cluster in mouse to a different compositional cluster in human.KeywordsMolecular evolutionCo-evolutionTriplet composonGene clustering