A revisit to quantitative PET with <sup class="a-plus-plus">18sup>F-FDOPA of high specific activity using a high-resolution condition in view of application to regenerative therapy

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• 作者：Go Akamatsu ; Akihito Ohnishi ; Kazuki Aita ; Hiroyuki Nishida…
• 关键词：18F ; FDOPA ; 11C ; raclopride ; PET ; Quantification ; High resolution
• 刊名：Annals of Nuclear Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：2
• 页码：163-171
• 全文大小：
• 刊物主题：Nuclear Medicine; Imaging / Radiology;
• 出版者：Springer Japan
• ISSN：1864-6433
• 卷排序：31

文摘

ObjectiveWith the advent of regenerative/cell therapy for Parkinson’s disease (PD), 18F-FDOPA has drawn new attention as a biomarker of the therapeutic that cannot be evaluated with radiopharmaceuticals for dopamine transporter. Since most previous 18F-FDOPA PET studies were carried out many years ago with a PET scanner of lower resolution and with 18F-FDOPA of low specific activity synthesized from 18F-F₂, we used a newer PET/CT scanner with a high-resolution condition and 18F-FDOPA synthesized from 18F-F−sup> to re-evaluate this technique on normal subjects and patients with PD, together with D₂ receptor imaging with 11C-raclopride (RAC).