Sleep-dependent memory consolidation and its implications for psychiatry

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• 作者：Monique Goerke ; Notger G. Müller ; Stefan Cohrs
• 关键词：Sleep ; Memory consolidation ; Insomnia ; Major depression ; Schizophrenia ; Post ; traumatic stress disorder
• 刊名：Journal of Neural Transmission
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：124
• 期：1-supp
• 页码：163-178
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Neurology; Psychiatry; Pharmacology/Toxicology; Neurosciences;
• 出版者：Springer Vienna
• ISSN：1435-1463
• 卷排序：124

文摘

Both sleep disturbance and memory impairment are very common in psychiatric disorders. Since sleep has been shown to play a role in the process of transferring newly acquired information into long-term memory, i.e., consolidation, it is important to highlight this link in the context of psychiatric disorders. Along these lines, after providing a brief overview of healthy human sleep, current neurobiological models on sleep-dependent memory consolidation and resultant opportunities to manipulate the memory consolidation process, recent findings on sleep disturbances and sleep-dependent memory consolidation in patients with insomnia, major depression, schizophrenia, and post-traumatic stress disorder are systematically reviewed. Furthermore, possible underlying neuropathologies and their implications on therapeutic strategies are discussed. This review aims at sensitizing the reader for recognizing sleep disturbances as a potential contributor to cognitive deficits in several disorders, a fact which is often overlooked up to date.