Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis

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• 作者：C. Zhang M.D (1)
  L. Chen Ph.D (1)
  Y. Gu M.D (1)
  
  1. Department of Orthopaedic Surgery ; The First Affiliated Hospital of Soochow University ; No 188 ShiziStreet ; 215006 ; Suzhou ; China
  
• 关键词：Matrix metalloproteinase ; Asian ; Caucasian ; Risk ; Susceptibility ; Matrixmetalloproteinase ; Asiat ; Kaukasier ; Risiko ; Pr盲disposition
• 刊名：Zeitschrift f篓鹿r Rheumatologie
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：74
• 期：3
• 页码：258-262
• 全文大小：442 KB
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• 刊物主题：Internal Medicine; Rheumatology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1250

文摘

Objective To determine the correlation between rheumatoid arthritis (RA) and polymorphisms of the matrix metalloproteinase (MMP) genes MMP-1 and MMP-3. Background The 1607聽1G/2G and 1171聽5A/6A polymorphisms of MMP genes MMP-1 and MMP-3 have been discovered to be functional, and may be conducive to RA. In order to determine whether MMP-1 and MMP-3 gene polymorphisms correlate with RA development, we performed a meta-analysis to further validate the function of these polymorphisms in RA. Methods We searched PubMed, ISI Web of Knowledge, MEDLINE, Embase, Google Scholar Chinese Biomedical Literature Database, and Wanfang Data to identify all published case鈥揷ontrol studies on the MMP-1-1607聽1G/2G and MMP-3-1171聽5A/6A polymorphisms and RA risk. Odds ratios (OR) and 95鈥? confidence intervals (CI) were used to estimate the association between these polymorphisms and RA risk. Results After being assessed, five articles fulfilled the inclusion criteria. To assess associations, the pooled OR with 95鈥?聽CIs was calculated. Neither the MMP-1-1607聽1G/2G nor the MMP-3-1171聽5A/6A polymorphism was statistically associated with RA in any of the five models, nor in the subgroup analysis models of MMP-3-1171聽5A/6A in Caucasian and Asian patients. Conclusion Our study suggests that MMP-1 and MMP-3 polymorphisms have no significant association with the risk of RA.