Salvage cryosurgery for locally recurrent prostate cancer after primary cryotherapy

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• 作者：Xiaofeng Chang ; Tieshi Liu ; Fan Zhang ; Xiaozhi Zhao…
• 关键词：Prostatic neoplasms ; Cryosurgery ; Recurrence ; Salvage ; Focal therapy
• 刊名：International Urology and Nephrology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：47
• 期：2
• 页码：301-305
• 全文大小：171 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Nephrology
  Urology and Andrology
  
• 出版者：Springer Netherlands
• ISSN：1573-2584

文摘

Objective To report our preliminary experience of salvage cryosurgery (SCS) for locally recurrent prostate cancer (PCa) after primary cryotherapy and determine the efficacy of cryoablation of the prostate in the salvage setting. Patients and methods We conducted a retrospective review of the records of all patients who underwent SCS for locally recurrent PCa after primary cryotherapy between February 2008 and March 2012. Patients were assessed after treatment by prostate-specific antigen (PSA) testing, transrectal ultrasonography, radiologic imaging, and biopsy. Biochemical failure was defined using the Phoenix criteria. Results Data from 12 patients who had undergone SCS were entered. Median age at SCS was 77.5?year. Before SCS, patients had a median PSA level of 2.5?ng/ml and median Gleason sum of 7. Patients underwent SCS at a median of 7.8?months after primary CS. Median PSA nadir after SCS was 1.32?ng/ml. The mean (range) follow-up was 33.5?months. Three patients were started on hormonal therapy for disease progression at a median post-SCS period of 12?months. Two patients underwent repeat cryoablation. Only one patient developed mild incontinence after SCS. Urethral sloughing occurred in one patient. Only two patients suffered from transient impotence. Conclusions It is feasible for patients with PCa to adopt SCS when primary cryotherapy has failed. The application of SCS also allows hormonal therapy to be deferred for a sufficient period of time.