Monitoring the HER2 copy number status in circulating tumor DNA by droplet digital PCR in patients with gastric cancer
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- 作者：Katsutoshi Shoda ; Daisuke Ichikawa ; Yuji Fujita ; Kiyoshi Masuda…
- 关键词：Gastric cancer ; HER2 ; DdPCR ; ctDNA ; Liquid biopsy
- 刊名：Gastric Cancer
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：20
- 期：1
- 页码：126-135
- 全文大小：1953KB
- 刊物类别：Medicine
- 刊物主题：Surgical Oncology; Oncology; Abdominal Surgery; Gastroenterology; Cancer Research;
- 出版者：Springer Japan
- ISSN：1436-3305
- 卷排序：20
文摘
BackgroundWe previously demonstrated the potential of circulating tumor DNA (ctDNA) for the amplification of detecting HER2 in patients with gastric cancer (GC). In the present study, we focused on the clinical courses of patients who developed recurrence with GC, and investigated the potential clinical utility of the ddPCR-based HER2 copy number (CN) as a marker for the temporal and/or spatial heterogeneities of GC during treatment progress.