Pharmacokinetics of mycophenolic acid in children with clinically stable idiopathic nephrotic syndrome receiving cyclosporine
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- 作者：Satoshi Hibino ; Takuhito Nagai ; Satoshi Yamakawa…
- 关键词：Pharmacokinetics ; Mycophenolate mofetil ; Mycophenolic acid ; Nephrotic syndrome ; Cyclosporine ; Children
- 刊名：Clinical and Experimental Nephrology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：21
- 期：1
- 页码：152-158
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Nephrology; Urology;
- 出版者：Springer Japan
- ISSN：1437-7799
- 卷排序：21
文摘
BackgroundThe suitable dosage regime of mycophenolate mofetil (MMF) based on the pharmacokinetics of mycophenoric acid (MPA) for pediatric patients with idiopathic nephrotic syndrome (INS) is controversial. The pharmacokinetics of MPA is influenced by renal function, serum albumin concentration, and concomitant medications, especially calcineurin inhibitors. This study analyzed the pharmacokinetics of MPA in clinically stable children with INS receiving cyclosporine (CyA).