Beneficial effect of persimmon leaves and bioactive compounds on thrombosis
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- 作者：Ri Ryu (1)
Un Ju Jung (2)
Yu-Ri Seo (1)
Hye-Jin Kim (3)
Byoung Seok Moon (3)
Jong-Sup Bae (4)
Dong Gun Lee (5)
Myung-Sook Choi (1) (2)
1. Department of Food Science and Nutrition ; Kyungpook National University ; Daegu ; 702-701 ; Korea
2. Center for Food and Nutritional Genomics Research ; Kyungpook National University ; Daegu ; 702-701 ; Korea
3. Foods R&D ; CJ Cheil Jedang Corporation ; Seoul ; 100-400 ; Korea
4. College of Pharmacy ; CMRI ; Research Institute of Pharmaceutical Sciences ; Kyungpook National University ; Daegu ; 702-701 ; Korea
5. School of Life Sciences ; College of Natural Sciences ; Kyungpook National University ; Daegu ; 702-701 ; Korea - 关键词：persimmon leaf ; anticoagulation ; antiplatelet
- 刊名：Food Science and Biotechnology
- 出版年：2015
- 出版时间：February 2015
- 年：2015
- 卷：24
- 期：1
- 页码：233-240
- 全文大小：309 KB
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- 刊物主题：Chemistry
Nutrition
Food Science - 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
- ISSN：2092-6456
文摘
The effects of ethanol extracts of persimmon leaves (EPL) and the major flavonoids catechin, epicatechin, and epicatechin gallate on blood coagulation and platelet aggregation were evaluated. Anticoagulant activities were examined by monitoring the activated partial thromboplastin time (aPTT) and the prothrombin time (PT). EPL significantly prolonged PT and aPTT. The aPTT was significantly increased in the presence of catechin, epicatechin, and epicatechin gallate, compared with controls. In order to determine the antiplatelet activity, arachidonic acid (AA), collagen, and adenosine diphosphate (ADP)-induced platelet aggregation were examined. PL and the major flavonoids significantly reduced AA-induced platelet aggregation, although they did not significantly affect ADP and collagen-induced platelet aggregation, compared with controls. EPL and the major flavonoids significantly inhibited serotonin, thromboxane A2, and soluble P-selectin generation, compared with controls. PL has potential for prevention and improvement of thrombosis by inhibiting blood coagulation and platelet activation.