Asymmetric dimethylarginine is associated with high-sensitivity C-reactive protein and early carotid atherosclerosis in women with previous gestational diabetes mellitus

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• 作者：Wei Xia ; Dajiang Li ; Chunquan Zhang ; Li Xu ; Wenliang Xu ; Yibing Shao
• 关键词：Asymmetric dimethylarginine ; Gestational diabetes mellitus ; C ; reactive protein ; Intima ; media thickness
• 刊名：Endocrine
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：48
• 期：2
• 页码：528-532
• 全文大小：181 KB
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• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, general;
• 出版者：Springer US
• ISSN：1559-0100

文摘

Asymmetric dimethylarginine (ADMA) is increased in subjects with previous gestational diabetes mellitus (GDM). The aim of this study was to investigate the relationship between serum ADMA levels and early carotid atherosclerosis in women with history of GDM. A total of 42 normoglycemic women with previous GDM and 42 age-matched healthy controls were enrolled. Serum levels of ADMA, lipids, insulin, fasting and 2-h glucose following 75-g oral glucose tolerance test, and high sensitivity C-reactive protein (hsCRP) were measured. Carotid atherosclerosis was evaluated by ultrasonographically determined intima-media thickness (IMT). Serum ADMA and hsCRP were higher in women with previous GDM compared to the healthy controls (0.72?±?0.16 vs. 0.41?±?0.15?μmol/L, p?p?p?ADMA was positively correlated with hsCRP (r?=?41, p?r?=?0.38, p?ADMA was a significant predictor for elevated carotid IMT in subjects with previous GDM after adjusting for traditional risk factors (β?=?0.26, p?=?0.017). Our data demonstrated that serum ADMA was associated with hsCRP and carotid IMT in normoglycemic women with previous GDM.