The associations of bedtime, nocturnal, and daytime sleep duration with bone mineral density in pre- and post-menopausal women

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• 作者：Kun Wang ; Yang Wu ; Yu Yang ; Jie Chen ; Danyu Zhang ; Yongxin Hu ; Zhoujun Liu…
• 关键词：Bedtime ; Nocturnal sleep duration ; Daytime sleep duration ; Bone mineral density (BMD) ; Osteoporosis
• 刊名：Endocrine
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：49
• 期：2
• 页码：538-548
• 全文大小：523 KB
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• 作者单位：Kun Wang (1)
  Yang Wu (2)
  Yu Yang (1)
  Jie Chen (1)
  Danyu Zhang (1)
  Yongxin Hu (1)
  Zhoujun Liu (1)
  Juan Xu (1)
  Qiaoxuan Shen (1)
  Niya Zhang (1)
  Xiaodong Mao (1)
  Chao Liu (1)
  
  1. Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100, Hongshan Road, Nanjing, 210028, China
  2. Department of Endocrinology, The First People’s Hospital of Changzhou, Third Affiliated Hospital of Suzhou University, 185, Juqian Road, Changzhou, 213003, China
  
• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, general;
• 出版者：Springer US
• ISSN：1559-0100

文摘

To explore the association of sleep patterns with bone mineral density (BMD) in pre- and post-menopausal women, we used a questionnaire to evaluate the sleep patterns and performed calcaneal quantitative ultrasound to estimate BMD, in 6,510 women aged 40?years or older, from June to November 2011 in Nanjing City. We found a 1.7-fold risk of osteoporosis in post-menopausalwomen with bedtime of ?:00 am (OR?=?1.69, 95?% CI 1.39-.13), compared to those whose bedtime of <0:00 am. post-menopausalwomen with excessive total sleep (>10?h vs. 8-?h, OR?=?1.54, 95?% CI 1.05-.02) were shown to have a higher risk of osteoporosis, however, this high risk was not detected in those with excessive nocturnal sleep (>10?h vs. 8-?h, OR?=?0.85, 95?% CI 0.62-.30). By contrast, post-menopausalwomen with inadequate nocturnal sleep (??h vs. 8-?h, OR?=?1.68, 95?% CI 1.32-.75), excessive daytime sleep (?80?min vs. 0?min, OR?=?1.52, 95?% CI 1.08-.13), and noontime nap (>60?min vs. 0?min: OR?=?1.37, 95?% CI 1.06-.76) were demonstrated to have higher risk of bone loss. Nevertheless, these associations were not found in premenopausal women. We conclude that delayed bedtime, nocturnal sleep deprivation, excessive daytime sleep, and noontime nap, but not reduced total sleep duration, could promote bone loss in post-menopausalwomen, which might be related to circadian rhythm disturbances. However, they have limited influences to BMD in women who were still in menstruating. Mechanism responsible for the phenomena warrants further investigation.