Biological role of 8-oxo-2'-deoxyguanosine

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• 作者：N. V. Marmiy ; D. S. Esipov
• 关键词：8 ; oxo ; 2’-deoxyguanosine ; antioxidant ; anti ; inflammatory action ; regulation of gene expression ; reparation ; review
• 刊名：Moscow University Biological Sciences Bulletin
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：70
• 期：4
• 页码：168-172
• 全文大小：153 KB
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• 作者单位：N. V. Marmiy (1)
  D. S. Esipov (1)
  
  1. Department of Biology, Moscow State University, Moscow, Russia
  
• 刊物主题：Biochemistry, general; Cell Biology; Life Sciences, general; Plant Sciences; Zoology;
• 出版者：Springer US
• ISSN：1934-791X

文摘

The review presents currently available data on the biological role of 8-oxo-2’-deoxyguanosine. This compound for a long time has been used successfully as a biomarker of oxidative stress and diseases associated with it. However, in recent years, an increasing number of publications has appeared reporting that biological role of 8-oxo-dG is not only a mutagenic one; it also is involved in the regulation of gene expression, in some processes of DNA repair, in the control of inflammatory and autoimmune reactions, and in the activation of antioxidant systems. Probably, 8-oxo-2’-deoxyguanosine could prospectively be used as a drug. Keywords 8-oxo-2’-deoxyguanosine antioxidant anti-inflammatory action regulation of gene expression reparation review