Clinical analysis of seborrheic keratoses in the ear: a retrospective study and literature review

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• 作者：Kang Woo Kim (1)
  Jiwon Chang (1)
  Sunkyu Lee (1)
  Gi Jung Im (1)
  Sung Won Chae (1)
  Hak Hyun Jung (1)
  June Choi (1)
  
  1. Department of Otorhinolaryngology ; Head and Neck Surgery ; Korea University College of Medicine ; 123 Jeokgeum-ro (Gojan-Dong) ; Dawon-gu ; Ansan ; Gyeonggi-Do ; 425-707 ; South Korea
  
• 关键词：Seborrheic keratoses ; Classification ; Ear
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：272
• 期：5
• 页码：1113-1117
• 全文大小：996 KB
• 参考文献：1. Izquierdo Velasquez, JC, Campos Mahecha, AM, Duarte Silva, JP (2012) Seborrheic keratosis of the external auditory canal. Otol Neurotol 33: pp. e61-e62 CrossRef
  2. Hafner, C, Vogt, T (2008) Seborrheic keratosis. J Dtsch Dermatol Ges 6: pp. 664-677 CrossRef
  3. Ishida, M, Ohsato, N, Okabe, H (2011) Basal cell carcinoma arising within a seborrheic keratosis with respect to immunohistochemical characteristics. Oncology lett 2: pp. 625-627
  4. Hafner, C, Vogt, T, Landthaler, M, Musebeck, J (2008) Somatic FGFR3 and PIK3CA mutations are present in familial seborrhoeic keratoses. Br J Dermatol 159: pp. 214-217 CrossRef
  5. Hafner, C, Lopez-Knowles, E, Luis, NM, Toll, A, Baselga, E, Fernandez-Casado, A, Hernandez, S, Ribe, A, Mentzel, T, Stoehr, R, Hofstaedter, F, Landthaler, M, Vogt, T, Pujol, RM, Hartmann, A, Real, FX (2007) Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proc Natl Acad Sci U S A 104: pp. 13450-13454 CrossRef
  6. Magliulo, G, Appiani, MC (2011) Seborrheic keratosis, keratotic type, of the external auditory canal. Otolaryngol Head Neck Surg 145: pp. 697-698 CrossRef
  7. Kyrmizakis, DE, Vrentzos, EE, Papadakis, CE, Chroniaris, NE, Bizakis, JG, Amanakis, ZE (2002) Seborrheic keratosis of the auricle: report of an unusual case. Ear Nose Throat J 81: pp. 107-109
  8. Kwon, OS, Hwang, EJ, Bae, JH, Park, HE, Lee, JC, Youn, JI, Chung, JH (2003) Seborrheic keratosis in the Korean males: causative role of sunlight. Photodermatol Photoimmunol Photomed 19: pp. 73-80 CrossRef
  9. Yeatman, JM, Kilkenny, M, Marks, R (1997) The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency?. Br J Dermatol 137: pp. 411-414 CrossRef
  10. Logie, A, Dunois-Larde, C, Rosty, C, Levrel, O, Blanche, M, Ribeiro, A, Gasc, JM, Jorcano, J, Werner, S, Sastre-Garau, X, Thiery, JP, Radvanyi, F (2005) Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet 14: pp. 1153-1160 CrossRef
  11. Kim, MP, Kim, GI, Jung, HH, Im, GJ (2008) A case of hyperkeratotic seborrheic keratosis of the external auditory canal. Korean J Otorhinolaryngol Head Neck Surg 51: pp. 405-407
  12. Jee, H, Lee, NR, Ahn, SK (2013) Case of seborrheic keratosis with underlying basal cell carcinoma suggesting a collision tumor. J Dermatol 40: pp. 837-839
  13. Repertinger, S, Wang, J, Adickes, E, Sarma, DP (2008) Melanoma in situ arising in seborrheic keratosis: a case report. Cases J 1: pp. 263 CrossRef
  14. Terada, T, Kamo, M, Baba, Y, Sugiura, M (2012) Microinvasive squamous cell carcinoma arising within seborrheic keratosis. Cutis 90: pp. 176-178
  15. Choi, JH (2012) Seborrheic keratosis of the external auditory canal. Otol Neurotol 33: pp. e27-e28 CrossRef
  16. Asagami, C, Muto, M, Hirota, T, Shimizu, T, Hamamoto, Y (1996) Anti-tumor effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in seborrheic keratosis. J Investig Dermatol Symp Proc 1: pp. 94-96
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Otorhinolaryngology
  Neurosurgery
  Head and Neck Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1434-4726

文摘

The pathogenesis of a seborrheic keratosis has not been fully elucidated. In the present study, we reviewed the literature to increase the awareness of this disease among otolaryngologists and to stress the need for prompt diagnosis and treatment. This was a retrospective study in seven patients presenting with seborrheic keratoses in the ear. We included only those patients in whom keratoses were confirmed by pathology after a complete excision. In six patients, seborrheic keratoses were observed in the external auditory canal, and in one patient, they were observed in the auricle. The subtype of keratoses was classified as acanthotic in six patients; one patient had an unclassified type associated with basal cell carcinoma. Seborrheic keratoses are benign skin tumors; however, the lesions can recur after removal. Moreover, an association between seborrheic keratoses and malignant skin tumors has been reported. Therefore, otolaryngologists should consider a complete removal and histological examination of seborrheic keratoses.