ICON: chronic rhinosinusitis
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- 作者：Claus Bachert (1)
Ruby Pawankar (2)
Luo Zhang (3)
Chaweewan Bunnag (4)
Wytske J Fokkens (5)
Daniel L Hamilos (6)
Orathai Jirapongsananuruk (4)
Robert Kern (7)
Eli O Meltzer (8)
Joaquim Mullol (9)
Robert Naclerio (10)
Renata Pilan (11)
Chae-Seo Rhee (12)
Harumi Suzaki (13)
Richard Voegels (14)
Michael Blaiss (15)
1. Upper Airways Research Laboratory (URL) ; University Hospital Ghent ; Kragujevac ; Belgium
2. Div. of Allergy ; Dept. of Pediatrics ; Nippon Medical School ; Tokyo ; Japan
3. Beijing Key Laboratory of Nasal diseases ; Beijing Institute of Otolaryngology ; Beijing ; China
4. Faculty of Medicine ; Siriraj Hospital Mahidol University ; Bangkok ; Thailand
5. Department of Otorhinolaryngology ; Academic Medical Centre ; Amsterdam ; The Netherlands
6. Division of Rheumatology ; Allergy & Immunology ; Massachusetts General Hospital ; Boston ; MA ; USA
7. Department of Otolaryngology Head and Neck Surgery ; Northwestern University Feinberg School of Medicine ; Chicago ; Illinois ; USA
8. Allergy & Asthma Medical Group & Research Center ; San Diego ; California ; USA
9. Rhinology Unit & Smell Clinic ; Hospital Cl铆nic 鈥?IDIBAPS ; Barcelona ; Catalonia ; Spain
10. Section of Otolaryngology Head and Neck Surgery ; Department of Surgery ; University of Chicago ; Chicago ; Illinois ; USA
11. Department of Otorhinolaryngology ; Clinics Hospital/University of Sao Paulo Medical School ; Kragujevac ; Brazil
12. Department of Otorhinolaryngology-Head and Neck Surgery ; Seoul National University Bundang Hospital ; Seongnam ; Seoul National University College of Medicine ; Seoul ; Korea
13. Dept. of Otorhinolaryngology ; Showa University ; Tokyo ; Japan
14. Department of Rhinology ; University of Sao Paulo Medical School ; Sao Paulo ; Brazil
15. University of Tennessee Health Science Center ; Memphis ; Tennessee - 关键词：Chronic rhinosinusitis ; Pharmacoeconomics ; Pathophysiology ; Phenotypes ; Genetics ; Co ; morbidities ; Treatment ; Biologicals ; Unmet needs
- 刊名：World Allergy Organization Journal
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：7
- 期：1
- 全文大小：2,031 KB
- 参考文献：1. Meltzer, EO, Hamilos, DL, Hadley, JA, Lanza, DC, Marple, BF, Nicklas, RA, Bachert, C, Baraniuk, J, Baroody, F, Benninger, M, Brook, I, Chowdhury, B, Druce, H, Durham, S, Ferguson, B, Gwaltney, J, Kaliner, M, Kennedy, D, Lund, V, Naclerio, R, Pawankar, R, Piccirillo, J, Rohan, P, Simon, R, Slavin, R, Togias, A, Wald, E, Zinreich, S (2004) Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol 114: pp. 155-212
2. Slavin, RG, Spector, SL, Bernstein, IL, Kaliner, MA, Kennedy, DW, Virant, FS, Wald, ER, Khan, DA, Blessing-Moore, J, Lang, DM, Nicklas, RA, Oppenheimer, JJ, Portnoy, JM, Schuller, DE, Tilles, SA, Borish, L, Nathan, RA, Smart, BA, Vandewalker, ML (2005) The diagnosis and management of sinusitis: a practice parameter update. J Allergy Clin Immunol 116: pp. S13-S47
3. Rosenfeld, RM (2007) Clinical practice guideline on adult sinusitis. Otolaryngol Head Neck Surg 137: pp. 365-377
4. Desrosiers, M, Evans, GA, Keith, PK, Wright, ED, Kaplan, A, Bouchard, J, Ciavarella, A, Doyle, PW, Javer, AR, Leith, ES, Mukherji, A, Robert Schellenberg, R, Small, P, Witterick, IJ (2011) Canadian clinical practice guidelines for acute and chronic rhinosinusitis. J Otolaryngol Head Neck Surg 40: pp. S99-S193
5. Fokkens, WJ, Lund, VJ, Mullol, J, Bachert, C, Alobid, I, Baroody, F, Cohen, N, Cervin, A, Douglas, R, Gevaert, P, Georgalas, C, Goossens, H, Harvey, R, Hellings, P, Hopkins, C, Jones, N, Joos, G, Kalogjera, L, Kern, B, Kowalski, M, Price, D, Riechelmann, H, Schlosser, R, Senior, B, Thomas, M, Toskala, E, Voegels, R, Wang De, Y, Wormald, PJ (2012) European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinology 2012 Suppl 23: pp. 1-298
6. Fokkens, WJ, Lund, VJ, Mullol, J, Bachert, C, Alobid, I, Baroody, F, Cohen, N, Cervin, A, Douglas, R, Gevaert, P, Georgalas, C, Goossens, H, Harvey, R, Hellings, P, Hopkins, C, Jones, N, Joos, G, Kalogjera, L, Kern, B, Kowalski, M, Price, D, Riechelmann, H, Schlosser, R, Senior, B, Thomas, M, Toskala, E, Voegels, R, Wang de, Y, Wormald, PJ (2012) EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 50: pp. 1-12
7. Jarvis, D, Newson, R, Lotvall, J, Hastan, D, Tomassen, P, Keil, T, Gjomarkaj, M, Forsberg, B, Gunnbjornsdottir, M, Minov, J, Brozek, G, Dahlen, SE, Toskala, E, Kowalski, ML, Olze, H, Howarth, P, Kr盲mer, U, Baelum, J, Loureiro, C, Kasper, L, Bousquet, PJ, Bousquet, J, Bachert, C, Fokkens, W, Burney, P (2012) Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe. Allergy 67: pp. 91-98
8. Kim, YS, Kim, NH, Seong, SY, Kim, KR, Lee, GB, Kim, KS (2011) Prevalence and risk factors of chronic rhinosinusitis in Korea. Am J Rhinol Allergy 25: pp. 117-121
9. Hastan, D, Fokkens, WJ, Bachert, C, Newson, RB, Bislimovska, J, Bockelbrink, A, Bousquet, PJ, Brozek, G, Bruno, A, Dahl茅n, SE, Forsberg, B, Gunnbj枚rnsd贸ttir, M, Kasper, L, Kr盲mer, U, Kowalski, ML, Lange, B, Lundb盲ck, B, Salagean, E, Todo-Bom, A, Tomassen, P, Toskala, E, van Drunen, CM, Bousquet, J, Zuberbier, T, Jarvis, D, Burney, P (2011) Chronic rhinosinusitis in Europe - an underestimated disease. A GA(2) LEN study. Allergy 66: pp. 1216-1223
10. Hamilos, DL (2011) Chronic rhinosinusitis: Epidemiology and medical management. J Allergy Clin Immunol 128: pp. 693-707
11. Pilan, RR, Pinna, FR, Bezerra, TF, Mori, RL, Padua, FG, Bento, RF, Perez-Novo, C, Bachert, C, Voegels, RL (2012) Prevalence of chronic rhinosinusitis in Sao Paulo. Rhinology 50: pp. 129-138
12. Bhattacharyya, N, Lee, LN (2010) Evaluating the diagnosis of chronic rhinosinusitis based on clinical guidelines and endoscopy. Otolaryngol Head Neck Surg 143: pp. 147-151
13. Fokkens, W, Lund, V, Mullol, J (2007) European position paper on rhinosinusitis and nasal polyps 2007. Rhinology 20: pp. 1-136
14. Bousquet, J, Bachert, C, Canonica, GW, Casale, TB, Cruz, AA, Lockey, RJ, Zuberbier, T (2009) Unmet needs in severe chronic upper airway disease (SCUAD). J Allergy Clin Immunol 124: pp. 428-433
15. Pilan RR, Pinna FR, Bezerra TF, Mori RL, Padua FG, Bento RF, Perez-Novo C, Bachert C, Voegels RL: Prevalence of chronic rhinosinusitis in Sao Paulo. / Rhinology 2012.,50(2):
16. Pleis, JR, Ward, BW, Lucas, JW (2010) Summary health statistics for U.S. adults: National Health Interview Survey, 2009. Vital Health Stat 249: pp. 1-207
17. Shashy RG, Moore EJ, Weaver A: Prevalence of the chronic sinusitis diagnosis in Olmsted County, Minnesota. / Arch Otolaryngol Head Neck Surg 2004.,130(3):
18. Chen Y, Dales R, Lin M: The epidemiology of chronic rhinosinusitis in Canadians. / Laryngoscope 2003.,113(7):
19. Anand VK: Epidemiology and economic impact of rhinosinusitis. / Ann Otol Rhinol Laryngol 2004.,113(5):
20. Bhattacharyya, N (2003) The economic burden and symptom manifestations of chronic rhinosinusitis. Am J Rhinol 17: pp. 27-32
21. Bhattacharyya N: Incremental health care utilization and expenditures for chronic rhinosinusitis in the United States. / Ann Otol Rhinol Laryngol 2011.,120(7):
22. Bhattacharyya, N (2010) Ambulatory sinus and nasal surgery in the United States: demographics and perioperative outcomes. Laryngoscope 120: pp. 635-638
23. Mfuna-Endam, L, Zhang, Y, Desrosiers, MY (2011) Genetics of rhinosinusitis. Curr Allergy Asthma Rep 11: pp. 236-246
24. Alexiou, A, Sourtzi, P, Dimakopoulou, K, Manolis, E, Velonakis, E (2011) Nasal polyps: heredity, allergies, and environmental and occupational exposure. J Otolaryngol Head Neck Surg 40: pp. 58-63
25. Cohen, NA, Widelitz, JS, Chiu, AG, Palmer, JN, Kennedy, DW (2006) Familial aggregation of sinonasal polyps correlates with severity of disease. J Otolaryngol Head Neck Surg 134: pp. 601-604
26. Rugina, M, Serrano, E, Klossek, JM, Crampette, L, Stoll, D, Bebear, JP, Perrahia, M, Rouvier, P, Peynegre, R (2002) Epidemiological and clinical aspects of nasal polyposis in France; the ORLI group experience. Rhinology 40: pp. 75-79
27. Jani, AL, Hamilos, DL (2005) Current thinking on the relationship between rhinosinusitis and asthma. J Asthma 42: pp. 1-7
28. Kountakis, SE, Arango, P, Bradley, D, Wade, ZK, Borish, L (2004) Molecular and cellular staging for the severity of chronic rhinosinusitis. Laryngoscope 114: pp. 1895-1905
29. Ramsey, B, Richardson, MA (1992) Impact of sinusitis in cystic fibrosis. J Allergy Clin Immunol 90: pp. 547-552
30. Jorissen, MB, De Boeck, K, Cuppens, H (1999) Genotype-phenotype correlations for the paranasal sinuses in cystic fibrosis. Am J Respir Crit Care Med 159: pp. 1412-1416
31. Wang, X, Moylan, B, Leopold, DA, Kim, J, Rubenstein, RC, Togias, A, Proud, D, Zeitlin, P, Cutting, G (2000) Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population. JAMA 284: pp. 1814-1819
32. Sobol, SE, Christodoulopoulos, P, Manoukian, JJ, Hauber, HP, Frenkiel, S, Desrosiers, M, Fukakusa, M, Schloss, M, Hamid, Q (2002) Cytokine profile of chronic sinusitis in patients with cystic fibrosis. Arch Otolaryngol Head Neck Surg 128: pp. 1295-1298
33. Drake-Lee, A (1992) Nasal polyps in identical twins. J Laryngol Otol 106: pp. 1084-1085
34. Greisner, WA, Settipane, GA (1996) Hereditary factor for nasal polyps. Allergy Asthma Proc 17: pp. 283-286
35. Lockey, RF, Rucknagel, DL, Vanselow, NA (1973) Familial occurrence of asthma, nasal polyps and aspirin intolerance. Ann Intern Med 78: pp. 57-63
36. Tewfik, MA, Bosse, Y, Al-Shemari, H, Desrosiers, M (2010) Genetics of chronic rhinosinusitis: a primer. J Otolaryngol Head Neck Surg 39: pp. 62-68
37. Moloney, JR, Oliver, RT (1980) HLA antigens, nasal polyps and asthma. Clin Otolaryngol Allied Sci 5: pp. 183-189
38. Luxenberger, W, Posch, U, Berghold, A, Hofmann, T, Lang-Loidolt, D (2000) HLA patterns in patients with nasal polyposis. Eur Arch Otorhinolaryngol 257: pp. 137-139
39. Schubert, MS, Hutcheson, PS, Graff, RJ, Santiago, L, Slavin, RG (2004) HLA-DQB1 *03 in allergic fungal sinusitis and other chronic hypertrophic rhinosinusitis disorders. J Allergy Clin Immunol 114: pp. 1376-1383
40. Molnar-Gabor, E, Endreffy, E, Rozsasi, A (2000) HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis. Laryngoscope 110: pp. 422-425
41. Ramirez-Anguiano, J, Yamamoto-Furusho, JK, Barquera, R, Beltran, O, Granados, J (2006) Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos. Otolaryngol Head Neck Surg 135: pp. 90-93
42. Fajardo-Dolci, G, Solorio-Abreu, J, Romero-Alvarez, JC, Zavaleta-Villa, B, Cerezo-Camacho, O, Jimenez-Lucio, R, Olivo-D铆az, A (2006) DQA1 and DQB1 association and nasal polyposis. Otolaryngol Head Neck Surg 135: pp. 243-247
43. Zhai, L, Sun, Y, Tang, L, Liu, H (2007) Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps. Ann Otol Rhinol Laryngol 116: pp. 66-68
44. Keles, B, Cora, T, Acar, H, Arbag, H, Inan, Z, Ozturk, K, Ozer, B (2008) Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis. Otolaryngol Head Neck Surg 139: pp. 580-585
45. Kim, JH, Park, BL, Cheong, HS, Pasaje, CF, Bae, JS, Park, JS, Uh, ST, Kim, YH, Kim, MK, Choi, IS, Choi, BW, Park, CS, Shin, HD (2012) HLA-DRA polymorphisms associated with risk of nasal polyposis in asthmatic patients. Am J Rhinol Allergy 26: pp. 12-17
46. Karjalainen, J, Joki-Erkkila, VP, Hulkkonen, J, Pessi, T, Nieminen, MM, Aromaa, A, Klaukka, T, Hurme, M (2003) The IL1A genotype is associated with nasal polyposis in asthmatic adults. Allergy 58: pp. 393-396
47. Erbek, SS, Yurtcu, E, Erbek, S, Atac, FB, Sahin, FI, Cakmak, O (2007) Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis. Arch Otolaryngol Head Neck Surg 133: pp. 705-709
48. Mfuna Endam, L, Cormier, C, Bosse, Y, Filali-Mouhim, A, Desrosiers, M (2010) Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study. Arch Otolaryngol Head Neck Surg 136: pp. 187-192
49. Batikhan, H, Gokcan, MK, Beder, E, Akar, N, Ozturk, A, Gerceker, M (2010) Association of the tumor necrosis factor-alpha -308 G/A polymorphism with nasal polyposis. Eur Arch Otorhinolaryngol 267: pp. 903-908
50. Bernstein, JM, Anon, JB, Rontal, M, Conroy, J, Wang, C, Sucheston, L (2009) Genetic polymorphisms in chronic hyperplastic sinusitis with nasal polyposis. Laryngoscope 119: pp. 1258-1264
51. Kim, SH, Yang, EM, Lee, HN, Cho, BY, Ye, YM, Park, HS (2009) Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis. Allergy 64: pp. 1221-1225
52. Buysschaert, ID, Grulois, V, Eloy, P, Jorissen, M, Rombaux, P, Bertrand, B, Collet, S, Bobic, S, Vlaminck, S, Hellings, PW, Lambrechts, D (2010) Genetic evidence for a role of IL33 in nasal polyposis. Allergy 65: pp. 616-622
53. Kim, SH, Park, HS, Holloway, JW, Shin, HD, Park, CS (2007) Association between a TGFbeta1 promoter polymorphism and rhinosinusitis in aspirin-intolerant asthmatic patients. Respir Med 101: pp. 490-495
54. Cormier, C, Bosse, Y, Mfuna, L, Hudson, TJ, Desrosiers, M (2009) Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis. J Otolaryngol Head Neck Surg 38: pp. 133-141
55. Yea, SS, Yang, YI, Park, SK, Jang, WH, Lee, SS, Seog, DH, Park, YH, Chun, JH (2006) Interleukin-4 C-590T polymorphism is associated with protection against nasal polyps in a Korean population. Am J Rhinol 20: pp. 550-553
56. Zhang, Y, Wang, X, Zhang, W, Han, D, Zhang, L, Bachert, C (2013) Polymorphisms in thymic stromal lymphopoietin gene demonstrate a gender and nasal polyposis-dependent association with chronic rhinosinusitis. Hum Immunol 74: pp. 241-248
57. Cheng, YK, Lin, CD, Chang, WC, Hwang, GY, Tsai, SW, Wan, L, Tsai, MH, Tsai, J, Tsai, FJ (2006) Increased prevalence of interleukin-1 receptor antagonist gene polymorphism in patients with chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 132: pp. 285-290
58. Endam, LM, Bosse, Y, Filali-Mouhim, A, Cormier, C, Boisvert, P, Boulet, LP, Hudson, T, Desrosiers, M (2009) Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis. Otolaryngol Head Neck Surg 140: pp. 741-747
59. Castano, R, Bosse, Y, Endam, LM, Desrosiers, M (2009) Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. Am J Rhinol Allergy 23: pp. 377-384
60. Castano, R, Bosse, Y, Endam, LM, Filali-Mouhim, A, Desrosiers, M (2010) c-MET pathway involvement in chronic rhinosinusitis: a genetic association analysis. Otolaryngol Head Neck Surg 142: pp. 665-671
61. Sitarek, P, Zielinska-Blizniewska, H, Dziki, L, Milonski, J, Przybylowska, K, Mucha, B, Olszewski, J, Majsterek, I (2012) Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA Cell Biol 31: pp. 1258-1266
62. Kilty, SJ, Desrosiers, MY (2008) Chronic sinusitis and alpha1-antitrypsin deficiency: potential role for protease in rhinosinusitis?. J Otolaryngol Head Neck Surg 37: pp. E179-E182
63. Kilty, SJ, Bosse, Y, Cormier, C, Endam, LM, Desrosiers, MY (2010) Polymorphisms in the SERPINA1 (Alpha-1-Antitrypsin) gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy. Am J Rhinol Allergy 24: pp. e4-e9
64. Park, CS, Cho, JH, Park, YJ (2011) Toll-like receptor 2 gene polymorphisms in a Korean population: association with chronic rhinosinusitis. Otolaryngol Head Neck Surg 144: pp. 96-100
65. Tewfik, MA, Bosse, Y, Lemire, M, Hudson, TJ, Vallee-Smejda, S, Al-Shemari, H, Laprise, C, Desrosiers, M (2009) Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. Allergy 64: pp. 746-753
66. Zhang, Y, Endam, LM, Filali-Mouhim, A, Bosse, Y, Castano, R, Desrosiers, M (2011) Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis. Am J Rhinol Allergy 25: pp. e49-e54
67. Al-Shemari, H, Bosse, Y, Hudson, TJ, Cabaluna, M, Duval, M, Lemire, M, Vallee-Smedja, S, Frenkiel, S, Desrosiers, M (2008) Influence of leukotriene gene polymorphisms on chronic rhinosinusitis. BMC Med Genet 9: pp. 21
68. Tournas, A, Mfuna, L, Bosse, Y, Filali-Mouhim, A, Grenier, JP, Desrosiers, M (2010) A pooling-based genome-wide association study implicates the p73 gene in chronic rhinosinusitis. J Otolaryngol Head Neck Surg 39: pp. 188-195
69. Lee, JS, Kim, JH, Bae, JS, Kim, JY, Park, TJ, Pasaje, CF, Park, BL, Cheong, HS, Uh, ST, Park, JS, Jang, AS, Kim, MK, Choi, IS, Park, CS, Shin, HD (2010) Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population. BMC Med Genet 11: pp. 138
70. Erbek, SS, Yurtcu, E, Erbek, S, Sahin, FI (2009) Matrix metalloproteinase-9 promoter gene polymorphism (-1562C>T) in nasal polyposis. Am J Rhinol Allergy 23: pp. 568-570
71. Wang, LF, Chien, CY, Tai, CF, Kuo, WR, Hsi, E, Juo, SH (2010) Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis. BMC Med Genet 11: pp. 85
72. Pasaje, CF, Bae, JS, Park, BL, Cheong, HS, Kim, JH, Jang, AS, Uh, ST, Park, CS, Shin, HD (2012) Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients. BMC Med Genet 13: pp. 2
73. Bosse, Y, Bacot, F, Montpetit, A, Rung, J, Qu, HQ, Engert, JC, Polychronakos, C, Hudson, TJ, Froguel, P, Sladek, R, Desrosiers, M (2009) Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans. Hum Genet 125: pp. 305-318
74. Zhang, Y, Endam, LM, Filali-Mouhim, A, Zhao, L, Desrosiers, M, Han, D, Zhang, L (2012) Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study. PLoS One 7: pp. e39247
75. Seiberling, KA, Church, CA, Herring, JL, Sowers, LC (2012) Epigenetics of chronic rhinosinusitis and the role of the eosinophil. Int Forum Allergy Rhinol 2: pp. 80-84
76. Cheong, HS, Park, SM, Kim, MO, Park, JS, Lee, JY, Byun, JY, Park, BL, Shin, HD, Park, CS (2011) Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics. Allergy 66: pp. 637-644
77. Liu, Z, Kim, J, Sypek, JP, Wang, IM, Horton, H, Oppenheim, FG, Bochner, BS (2004) Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray. J Allergy Clin Immunol 114: pp. 783-790
78. Zhang, XH, Zhang, YN, Li, HB, Hu, CY, Wang, N, Cao, PP, Liao, B, Lu, X, Cui, YH, Liu, Z (2012) Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 185: pp. 140-151
79. Zhang, YN, Cao, PP, Zhang, XH, Lu, X, Liu, Z (2012) Expression of microRNA machinery proteins in different types of chronic rhinosinusitis. Laryngoscope 122: pp. 2621-2627
80. Zhang, XH, Zhang, YN, Liu, Z (2014) MicroRNA in chronic rhinosinusitis and allergic rhinitis. Curr Allergy Asthma Rep 14: pp. 415
81. Van Bruaene, N, Bachert, C (2011) Tissue remodeling in chronic rhinosinusitis. Curr Opin Allergy Clin Immunol 11: pp. 8-11
82. Lim, YS, Won, TB, Shim, WS, Kim, YM, Kim, JW, Lee, CH, Min, YG, Rhee, CS (2007) Induction of airway remodeling of nasal mucosa by repetitive allergen challenge in a murine model of allergic rhinitis. Ann Allergy Asthma Immunol 98: pp. 22-31
83. Shin, HW, Han, DH, Lim, YS, Kim, HJ, Kim, DY, Lee, CH, Min, YG, Rhee, CS (2009) Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity. Otolaryngol Head Neck Surg 141: pp. 442-447
84. Van Bruaene, N, Derycke, L, Perez-Novo, CA, Gevaert, P, Holtappels, G, De Ruyck, N, Cuvelier, C, Van Cauwenberge, P, Bachert, C (2009) TGF-尾 signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol 124: pp. 253-259
85. Van Bruaene, N, Perez Novo, C, Deruyck, N, Holtappels, G, Van Cauwenberge, P, Bachert, C (2012) Inflammation and remodeling patterns in early-stage chronic rhinosinusitis. Clin Exp Allergy 42: pp. 883-890
86. Yang, YC, Zhang, N, Van Crombruggen, K, Hu, GU, Hong, SL, Bachert, C (2012) Transforming growth factor beta1 in inflammatory airway disease: A key for understanding inflammation and remodeling. Allergy 67: pp. 1193-1202
87. Li, X, Meng, J, Liu, F, Zhang, N, Zhang, J, Holtappels, G, Ba, L, Zhou, P, Zheng, Y, Liu, S, Lin, P, Bachert, C (2010) Expression of transforming growth factor-尾, matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in Chinese chronic rhinosinusitis patients with and without nasal polyps. J Allergy Clin Immunol 125: pp. 1061-1068
88. De Borja Callejas, F, Picado, C, Mart铆nez-Ant贸n, A, Alobid, I, Pujols, L, Valero, A, Roca-Ferrer, J, Mullol, J (2013) Differential expression of remodeling markers by tissue structure in nasal polyposis. Am J Rhinol Allergy 27: pp. e69-e74
89. Sejima, T, Holtappels, G, Bachert, C (2011) The expression of fibrinolytic components in chronic paranasal sinus disease. Am J Rhinol Allergy 25: pp. 1-6
90. Takabayashi, T, Kato, A, Peters, AT, Hulse, KE, Suh, LA, Carter, R, Norton, J, Grammer, LC, Cho, SH, Tan, BK, Chandra, RK, Conley, DB, Kern, RC, Fujieda, S, Schleimer, RP (2013) Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression. Am J Respir Crit Care Med 187: pp. 49-57
91. Huvenne, W, Nan, Z, Tijsma, E, Hissong, B, Huurdeman, J, Holtappels, G, Claeys, S, Van Cauwenberge, P, Nelis, H, Coenye, T, Bachert, C (2008) A pilot study using doxycycline-releasing stents to ameliorate postoperative healing quality after sinus surgery. Wound Repair Reg 16: pp. 757-767
92. Van Zele, T, Gevaert, P, Holtappels, G, Beule, A, Wormald, PJ, Mayr, S, Hens, G, Hellings, P, Ebbens, FA, Fokkens, W, Van Cauwenberge, P, Bachert, C (2010) Oral steroids and doxycycline in nasal polyps: two different approaches to treat nasal polyps. J Allergy Clin Immunol 125: pp. 1069-1076
93. Bassiouni, A, Chen, PG, Wormald, PJ (2013) Mucosal remodeling and reversibility in chronic rhinosinusitis. Curr Opin Allergy Clin Immunol 13: pp. 4-12
94. Cutting, GR (2005) Modifier genetics: cystic fibrosis. Annu Rev Genomics Hum Genet 6: pp. 237-260
95. Antunes, MB, Gudis, DA, Cohen, NA (2009) Epithelium, cilia, and mucus: their importance in chronic rhinosinusitis. Immunol Allergy Clin North Am 29: pp. 631-643
96. Chen, B, Antunes, MB, Claire, SE, Palmer, JN, Chiu, AG, Kennedy, DW, Cohen, NA (2007) Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction. Am J Rhinol 21: pp. 346-353
97. Saito, D, Innes, A, Pletcher, S (2010) Rheologic properties of sinonasal mucus in patients with chronic sinusitis. Am J Rhinol Allergy 24: pp. 1-5
98. Zuckerman, JD, Lee, WY, DelGaudio, JM, Moore, CE, Nava, P, Nusrat, A, Parkos, CA (2008) Pathophysiology of nasal polyposis: the role of desmosomal junctions. Am J Rhinol 22: pp. 589-597
99. Rogers, G, Beste, KEH, Parkos, CA, Nusrat, A, DelGaudio, JM, Wise, SK (2011) Epithelial tight junction alterations in nasal polyposis. Internat Forum Allergy Rhinolo 1: pp. 50-54
100. Soyka, MB, Wawrzyniak, P, Eiwegger, T, Holzmann, D, Treis, A, Wanke, K, Kast, JI, Akdis, CA (2012) Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-纬 and IL-4. J Allergy Clin Immunol 130: pp. 1087-1096
101. Den Beste, KA, Hoddeson, EK, Parkos, CA, Nusrat, A, Wise, SK (2013) Epithelial permeability alterations in an in vitro air-liquid interface model of allergic fungal rhinosinusitis. Internat Forum Allergy Rhinol 3: pp. 19-25
102. Richer, SL, Truong-Tran, AQ, Conley, DB, Carter, R, Vermylen, D, Grammer, LC, Peters, AT, Chandra, R, Harris, K, Kern, R, Schleimer, R (2008) Epithelial genes in chronic rhinosinusitis with and without nasal polyps. Am J Rhinol 22: pp. 228-234
103. Fruth, K, Goeble, G, Koutsimpelas, D, Gosepath, J, Schmidtmann, I, Mann, WJ, Brieger, J (2012) Low SPINK5 Expression in Chronic Rhinosinusitis. Laryngoscope 122: pp. 1198-1204
104. Sha, Q, Truong-Tran, AQ, Plitt, JR, Beck, LA, Schleimer, RP (2004) Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol 31: pp. 358-364
105. Kato, A, Schleimer, RP (2007) Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity. Curr Opin Immunol 19: pp. 711-720
106. Matzinger, P (2002) danger model: a renewed sense of self. Science 12;296: pp. 301-305
107. Bianchi, ME, Manfredi, AA (2009) Immunology. Dangers in and out. Science 27;323: pp. 1683-1684
108. Lane, AP, Truong-Tran, QA, Schleimer, RP (2006) Altered expression of genes associated with innate immunity and inflammation in recalcitrant rhinosinusitis with polyps. Am J Rhinol 20: pp. 138-144
109. Dong, Z, Yang, Z, Wang, C (2005) Expression of TLR2 and TLR4 messenger RNA in the epithelial cells of the nasal airway. Am J Rhinol 19: pp. 236-239
110. Claeys, S, Van Hoecke, H, Holtappels, G, Gevaert, P, De Belder, T, Verhasselt, B, Van Cauwenberge, P, Bachert, C (2005) Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators. Clin Exp Allergy 35: pp. 467-472
111. Ramanathan, M, Lee, WK, Dubin, MG, Lin, S, Spannhake, EW, Lane, AP (2007) Sinonasal epithelial cell expression of toll-like receptor 9 is decreased in chronic rhinosinusitis with polyps. Am J Rhinol 21: pp. 110-116
112. Lee, RJ, Xiong, G, Kofonow, JM, Chen, B, Lysenko, A, Jiang, P, Abraham, V, Doghramji, L, Adappa, ND, Palmer, JN, Kennedy, DW, Beauchamp, GK, Doulias, PT, Ischiropoulos, H, Kreindler, JL, Reed, DR, Cohen, NA (2012) T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest 122: pp. 4145-4159
113. Adadppa, ND, Howland, TJ, Palmer, JN, Kennedy, DW, Doghramji, L, Lysenko, A, Reed, DR, Lee, RJ, Cohen, NA (2013) Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention. Int Forum Allergy Rhinol 3: pp. 184-187
114. Avila, PC, Schleimer, RP Airway Epithelium. In: Kay, AB, Kaplan, AP, Bousquet, J, Holt, PG eds. (2008) Allergy and allergic diseases. Wiley-Blackwell, Chichester, West Sussex, UK ; Hoboken, NJ
115. Ooi, EH, Psaltis, AJ, Witterick, IJ, Wormald, PJ (2010) Innate immunity. Otolaryngol Clin North Am 43: pp. 473-487
116. Laudien, M, Dressel, S, Harder, J, Glaser, R (2011) Differential expression pattern of antimicrobial peptides in nasal mucosa and secretion. Rhinology 49: pp. 107-111
117. Wolk, K, Kunz, S, Witte, E, Friedrich, M, Asadullah, K, Sabat, R (2004) IL-22 increases the innate immunity of tissues. Immunity 21: pp. 241-254
118. Wolk, K, Witte, E, Wallace, E, Docke, WD, Kunz, S, Asadullah, K, Volk, HD, Sterry, W, Sabat, R (2006) IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 36: pp. 1309-1323
119. Pickert, G, Neufert, C, Leppkes, M, Zheng, Y, Wittkopf, N, Warntjen, M, Lehr, HA, Hirth, S, Weigmann, B, Wirtz, S, Ouyang, W, Neurath, MF, Becker, C (2009) STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med 206: pp. 1465-1472
120. Aujla, SJ, Chan, YR, Zheng, M, Fei, M, Askew, DJ, Pociask, DA, Reinhart, TA, McAllister, F, Edeal, J, Gaus, K, Husain, S, Kreindler, JL, Dubin, PJ, Pilewski, JM, Myerburg, MM, Mason, CA, Iwakura, Y, Kolls, JK (2008) IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 14: pp. 275-281
121. Hulse K, Norton J, Harris K, Conley D, Chandra R, Kern R, Peters A, Grammer L, Cohen E, Singh R, Carter R, Suh L, Schleimer R: Epithelial STAT3 activation is associated with expression of the antimicrobial peptide S100A7. / J Immunol 2010.,184(14):
122. Aujla, SJ, Kolls, JK (2009) IL-22: a critical mediator in mucosal host defense. J Mol Med 87: pp. 451-454
123. Psaltis, AJ, Weitzel, EK, Ha, KR, Wormald, PJ (2008) The effect of bacterial biofilms on post-sinus surgical outcomes. Am J Rhinol 22: pp. 1-6
124. Psaltis, AJ, Bruhn, MA, Ooi, EH, Tan, LW, Wormald, PJ (2007) Nasal mucosa expression of lactoferrin in patients with chronic rhinosinusitis. Laryngoscope 117: pp. 2030-2035
125. Tieu, DD, Peters, AT, Carter, RG, Suh, L, Conley, DB, Chandra, R, Norton, J, Grammer, LC, Harris, KE, Kato, A, Kern, RC, Schleimer, RP (2010) Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. J Allergy Clin Immunol 125: pp. 667-675
126. Meyer, JE, Harder, J, Sipos, B, Maune, S, Kloppel, G, Bartels, J, Schr枚der, JM, Gl盲ser, R (2008) Psoriasin (S100A7) is a principal antimicrobial peptide of the human tongue. Mucosal Immunol 1: pp. 239-243
127. Seshadri, S, Rosati, M, Lin, D, Carter, J, Norton, JE, Kato, A, Chandra, RK, Harris, KE, Chu, HW, Peters, AT, Tan, BK, Conley, DB, Grammer, LC, Kern, RC, Schleimer, RP (2011) Reduced expression of antimicrobial palate, lung and nasal epithelial clone (PLUNC) protein in polyps from patients with chronic rhinosinusitis is due to decreased number of glands. J Allergy Clin Immunol 127: pp. AB141
128. Ramanathan, M, Spannhake, EW, Lane, AP (2007) Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor. Laryngoscope 117: pp. 1839-1843
129. Peters, AT, Kato, A, Zhang, N, Conley, DB, Suh, L, Tancowny, B, Carter, D, Carr, T, Radtke, M, Hulse, KE, Seshadri, S, Chandra, R, Grammer, LC, Harris, KE, Kern, R, Schleimer, RP (2010) Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 125: pp. 397-403
130. Tieu, DD, Kern, RC, Schleimer, RP (2009) Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis. J Allergy Clin Immunol 124: pp. 37-42
131. Vroling, AB, Fokkens, WJ, Van Drunen, CM (2008) How epithelial cells detect danger: aiding the immune response. Allergy 63: pp. 1110-1123
132. Kowalski, ML, Lewandowska-Polak, A, Wozniak, J, Ptasinska, A, Jankowski, A, Wagrowska-Danilewicz, M, Pawliczak, R (2005) Association of stem cell factor expression in nasal polyp epithelial cells with aspirin sensitivity and asthma. Allergy 60: pp. 631-637
133. Nishi, Y, Takeno, S, Ishino, T, Hirakawa, K (2009) Glucocorticoids suppress NF-kappaB activation induced by LPS and PGN in paranasal sinus epithelial cells. Rhinology 47: pp. 413-418
134. Kato, A, Peters, A, Suh, L, Carter, R, Harris, KE, Chandra, R, Conley, D, Grammer, LC, Kern, R, Schleimer, RP (2008) Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 121: pp. 1385-1392
135. Lu, X, Zhang, XH, Wang, H, Long, XB, You, XJ, Gao, QX, Cui, YH, Lui, Z (2009) Expression of osteopontin in chronic rhinosinusitis with and without nasal polyps. Allergy 64: pp. 104-111
136. Keswani, A, Chustz, RT, Suh, L, Carter, R, Peters, AT, Tan, BK, Chandra, R, Kim, SH, Azam, T, Dinarello, CA, Kern, RC, Schleimer RP Kato, A (2012) Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps. Allergy 67: pp. 25-32
137. Lambrecht, BN, Hammad, H (2012) The airway epithelium in asthma. Nature Medicine 18: pp. 684-692
138. Sanos, S, Diefenbach, A (2013) Innate lymphoid cells: from border protection to the initiation of inflammatory diseases. Immunol Cell Biol 91: pp. 215-224
139. Hansel, TT, Johnston, SL, Openshaw, PJ (2013) Microbes and mucosal immune responses in asthma. Lancet 381: pp. 861-873
140. Mjoesberg, J, Trifari, S, Crellin, NK, Peters, CP, Van Drunen, CM, Piet, B, Fokkens, W, Cupedo, T, Spits, H (2011) Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nature Immunology 12: pp. 1055-1062
141. Allakhverdi, Z, Comeau, MR, Smith, DE, Toy, D, Endam, LM, Desrosiers, M, Liu, YJ, Howie, KJ, Denburg, JA, Gauvreau, GM, Delespesse, G (2009) CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation. J Allergy Clin Immunol 123: pp. 472-478
142. Nonaka, M, Fukumoto, A, Ogihara, N, Sakanushi, A, Pawankar, R, Yagi, T (2010) Synergistic induction of thymic stromal lymphopoietin by tumor necrosis factor alpha and Th2 cytokine in nasal polyp fibroblasts. Am J Rhinol Allergy 24: pp. e14-e18
143. Liu, T, Li, TL, Zhao, F, Xie, C, Liu, AM, Chen, X, Song, C, Cheng, L, Yang, PC (2011) Role of thymic stromal lymphopoietin in the pathogenesis of nasal polyposis. Am J Med Sci 341: pp. 40-47
144. Kimura, S, Pawankar, R, Mori, S, Nonaka, M, Masuno, S, Yagi, T, Okubo, K (2011) Increased expression and role of thymic stromal lymphopoietin in nasal polyposis. Allergy Asthma Immunol Res 3: pp. 186-193
145. Nagarkar, DR, Poposki, JA, Tan, BK, Comeau, MR, Peters, AT, Hulse, K, Suh, LA, Norton, J, Harris, KE, Grammer, LC, Chandra, RK, Conley, DB, Kern, RC, Schleimer, RP, Kato, A (2013) Increased activity of thymic stromal lymphopoietin in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol 132: pp. 593-600.e12
146. Reh, DD, Wang, Y, Ramanathan, M, Lane, AP (2010) Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33. Am J Rhinol Allergy 24: pp. 105-109
147. Schleimer, R, Kato, A, Kern, RC (2011) 鈥淓osinophils in CRS鈥? Eosinoph Health Dis.
148. Takabayashi, T, Kato, A, Peters, AT, Suh, LA, Carter, R, Norton, J, Grammer, LC, Tan, BK, Chandra, RK, Conley, DB, Kern, RC, Fujieda, S, Schleimer, RP (2012) Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 130: pp. 410-20.e5
149. Krysko, O, Holtappels, G, Zhang, N, Kubica, M, Deswarte, K, Derycke, L, Claeys, S, Hammad, H, Brusselle, GG, Vandenabeele, P, Krysko, DV, Bachert, C (2011) Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis. Allergy 66: pp. 396-403
150. Lundberg, JO, Farkas-Szallasi, T, Weitzberg, E, Rinder, J, Lidholm, J, Anggaard, A, H枚kfelt, T, Lundberg, JM, Alving, K (1995) High nitric oxide production in human paranasal sinuses. Nat Med 1: pp. 370-373
151. Moskwa, P, Lorentzen, D, Excoffon, KJ, Zabner, J, McCray, PB, Nauseef, WM, Dupuy, C, B谩nfi, B (2007) A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med 175: pp. 174-183
152. Colantonio, D, Brouillette, L, Parikh, A, Scadding, GK (2002) Paradoxical low nasal nitric oxide in nasal polyposis. Clin Exp Allergy 32: pp. 698-701
153. Ragab, SM, Lund, VJ, Saleh, HA, Scadding, G (2006) Nasal nitric oxide in objective evaluation of chronic rhinosinusitis therapy. Allergy 61: pp. 717-724
154. Phillips, PS, Sacks, R, Marcells, GN, Cohen, NA, Harvey, RJ (2011) Nasal nitric oxide and sinonasal disease: a systematic review of published evidence. Otolaryngol Head Neck Surg 144: pp. 159-169
155. Roca-Ferrer, J, Garcia-Garcia, FJ, Pereda, J, Perez-Gonzalez, M, Pujols, L, Alobid, I, Mullol, J, Picado, C (2011) Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma. J Allergy Clin Immunol 128: pp. 66-72 e1
156. Van Crombruggen, K, Zhang, N, Gevaert, P, Tomassen, P, Bachert, C (2011) Pathogenesis of chronic rhinosinusitis: Inflammation. J Allergy Clin Immunol 128: pp. 728-732
157. Chandra, RK, Lin, D, Tan, B, Tudor, RS, Conley, DB, Peters, AT, Grammer, LC, Schleimer, RP, Kern, RC (2011) Chronic rhinosinusitis in the setting of other chronic inflammatory diseases. Am J Otolaryngol 32: pp. 388-391
158. Kern, RC, Conley, DB, Walsh, W, Chandra, R, Kato, A, Tripathi-Peters, A, Grammer, LC, Schleimer, RP (2008) Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis. Am J Rhinol 22: pp. 549-559
159. Van Zele, T, Claeys, S, Gevaert, P, Holtappels, G, Van Cauwenberge, P, Bachert, C (2006) Differen-tiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 61: pp. 1280-1289
160. Van Zhang Nan, T, Zele, CP-N, Van Bruaene, N, Holtappels, G, DeRuyck, N, Van Cauwenberge, P, Bachert, C (2008) Different types of T effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol 122: pp. 961-968
161. Derycke, L, Zhang, N, Holtappels, G, Dutr茅, T, Bachert, C (2012) IL-17A as a regulator of neutrophil survival in nasal polyp disease of patients with and without cystic fibrosis. J Cyst Fibros 11: pp. 193-200
162. Bachert, C, Nan, Z, Gabriele, H, Lizzi De, L, Cauwenberge, P c, Liu, S, Ping, L, Jean, B, Van Steen, K (2010) Presence of IL-5 protein and IgE-antibodies to staphylococcal enterotoxins in nasal polyps is associated with co-morbid asthma. J Allergy Clin Immunol 126: pp. 962-968
163. Ba, L, Zhang, N, Lin, P, Liu, S, Bachert, C (2011) Bacterial colonization is associated with different inflammatory pattern in rhinosinusitis with nasal polyps. Allergy 66: pp. 1296-1303
164. Van Bruaene, N, Perez-Novo, C, Basinski, T, Van Zele, T, Holtappels, G, Schmidt-Weber, C, Akdis, C, Van Cauwenberge, PC, Gevaert, P (2008) T cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol 121: pp. 1435-1441
165. Roongrotwattanasiri, K, Pawankar, R, Kimura, S, Mori, S, Nonaka, M, Yagi, T (2012) Decreased Expression of FOXP3 in Nasal Polyposis. Allergy Asthma Immunol Res 4: pp. 24-30
166. Kim, YM, Munoz, A, Hwang, PH, Nadeau, KC (2010) Migration of regulatory T cells toward airway epithelial cells is impaired in chronic rhinosinusitis with nasal polyposis. Clin Immunol 137: pp. 111-121
167. Feng, L, Zhang, N, Zhang, J, Krysko, O, Zhang, Q, Xian, J, Derycke, L, Qi, Y, Li, K, Liu, S, Lin, P, Bachert, C (2013) Foxp3 in human airway regulatory T cells is regulated by SOCS3. J Allergy Clin Immunol 132: pp. 1314-1321
168. Calus, L, Derycke, L, Dullaers, M, Van Zele, T, De Ruyck, N, Holtappels, G, Lambrecht, B, Bachert, C, Gevaert, P (2013) IL-21 is increased in nasal polyposis and after stimulation with Staphylococcus aureus enterotoxin B. J Allergy Clin Immunol.
169. Gevaert, P, Nouri-Aria, KT, Wu, H, Harper, CE, Takhar, P, Fear, DJ, Acke, F, Deruyck, N, Banfield, G, Kariyawasam, HH, Bachert, C, Durham, SR, Gould, HJ (2013) Local receptor revision and class switching to ige in chronic rhinosinusitis with nasal polyps. Allergy 68: pp. 55-63
170. Mechtcheriakova, D, Sobanov, J, Knittelfelder, R, Bachert, C, Jensen-Jarolim, E (2011) Gene expression pattern associated with activation-induced cytidine deaminase, AID, in chronic paranasal disorders. PlosOne 6: pp. e25611
171. Baraniuk, JN Physiology of sinusitis. In: Druce, HM eds. (1994) Sinusitis: pathophysiology and treatment. Marcel Dekker, New York, pp. 19-39
172. Van Cauwenberge, P, Ingels, K (1996) Effects of viral and bacterial infection on nasal and sinus mucosa. Acta Otolaryngol (Stockh) 116: pp. 316-321
173. Calenoff, E, McMahan, JT, Herzon, GD, Kern, RC, Ghadge, GD, Hanson, DG (1993) Bacterial allergy in nasal polyposis. A new method for quantifying specific IgE. Arch Otolaryngol Head Neck Surg 119: pp. 830-836
174. Mempel, M, Lina, G, Hojka, M, Schnopp, C, Seidl, HP, Schafer, T, Ring, J, Vandenesch, F, Abeck, D (2003) High prevalence of superantigens associated with the egc locus in Staphylococcus aureus isolates from patients with atopic eczema. Eur J Clin Microbiol Infect Dis 22: pp. 306-309
175. Schubert, MS (2001) A superantigen hypothesis for the pathogenesis of chronic hypertrophic rhinosinusitis, allergic fungal sinusitis, and related disorders. Ann Allergy Asthma Immunol 87: pp. 181-188
176. Bachert, C, Gevaert, P, Holtappels, G, Johansson, SG, Van Cauwenberge, P (2001) Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol 107: pp. 607-614
177. Bachert, C, Wagenmann, M, Hauser, U, Rudack, C (1997) IL-5 is upregulated in human nasal polyp tissue. J Allergy Clin Immunol 99: pp. 837-842
178. Min, YG, Lee, CH, Rhee, CS, Hong, SK, Kwon, SH (1999) Increased expression of IL-4, IL-5, IFN-gamma, IL-6, IL-8, and TGF-beta mRNAs in maxillary mucosa of patients with chronic sinusitis. Am J Rhinol 13: pp. 339-343
179. Perez-Novo, CA, Watelet, JB, Claeys, C, Van Cauwenberge, P, Bachert, C (2005) Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. J Allergy Clin Immunol 115: pp. 1189-1196
180. Van Zele, T, Gevaert, P, Watelet, JB, Claeys, G, Holtappels, G, Claeys, C, Van Cauwenberge, P, Bachert, C (2004) Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol 114: pp. 981-983
181. Perez-Novo, CA, Kowalski, ML, Kuna, P, Ptasinska, A, Holtappels, G, Van Cauwenberge, P, Gevaert, P, Johannson, S, Bachert, C (2004) Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: Studies on the relationship. Internat Arch Allergy Immunol 133: pp. 255-260
182. Van Zele, T, Gevaert, P, Holtappels, G, Van Cauwenberge, P, Bachert, C (2007) Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy 37: pp. 1840-1847
183. Gevaert, P, Holtappels, G, Johansson, SG, Cuvelier, C, Cauwenberge, P, Bachert, C (2005) Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue. Allergy 60: pp. 71-79
184. Zhang, N, Holtappels, G, Gevaert, P, Patou, J, Dhaliwal, B, Gould, H, Bachert, C (2011) Mucosal tissue polyclonal IgE is functional in response to allergen and SEB. Allergy 66: pp. 141-148
185. Hamilos, DL, Leung, DYM, Huston, DP, Kamil, A, Wood, R, Hamid, Q (1998) GM-CSF, IL-5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP). Clin Exp Allergy 28: pp. 1145-1152
186. Nonaka, M, Pawankar, R, Saji, F, Yagi, T (1999) Distinct expression of RANTES and GM-CSF by lipopolysaccharide in human nasal fibroblasts but not in other airway fibroblasts. Int Arch Allergy Immunol 119: pp. 314-321
187. Pawankar, R (2001) Mast cells as or orchestrates of the allergic reaction: The IgE-IgE mast cell network. Curr Opin Allergy Clin Immunol 1: pp. 3-6
188. Hamilos, DL, Leung, DYM, Wood, R, Cunningham, L, Bean, DK, Yasruel, S, Schotman, E, Hamid, Q (1995) Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol 96: pp. 537-544
189. Schleimer, RP, Kato, A, Peters, A, Conley, D, Kim, J, Liu, MC, Harris, KE, Kuperman, DA, Chandra, R, Favoreto, S, Avila, PC, Grammer, LC, Kern, RC (2009) Epithelium, inflammation, and immunity in the upper airways of humans: studies in chronic rhinosinusitis. Proc Am Thorac Soc 6: pp. 288-294
190. Di Lorenzo, G, Drago, A, Esposito Pellitteri, M, Candore, G, Colombo, A, Gervasi, F, Pacor, ML, Purello D'Ambrosio, F, Caruso, C (2001) Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis. Int Arch Allergy Immunol 125: pp. 164-175
191. Pawankar, R, Okuda, M, Yssel, H, Okumura, K, Ra, C (1997) Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells. J Clin Invest 99: pp. 1492-1499
192. Vagic, D, Ferencic, Z, Drvis, P, Geber, G, Dzidic, S, Baudoin, T, Kalogjera, L (2008) Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics. Eur Arch Otorhinolaryngol 265: pp. 1205-1209
193. Cerutti, A, Chen, K, Chorny, A (2011) Immunoglobulin responses at the mucosal interface. Annu Rev Immunol 29: pp. 273-293
194. Bachert, C, Zhang, N (2012) Chronic rhinosinusitis and asthma: novel understanding of the role of IgE 鈥渁bove atopy. J Intern Med 272: pp. 133-143
195. Gevaert, P, Calus, L, Van Zele, T, Blomme, K, De Ruyck, N, Bauters, W, Hellings, P, Brusselle, G, De Bacquer, D, Van Cauwenberge, P, Bachert, C (2013) Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J Allergy Clin Immunol 131: pp. 110-116
196. Akdis, M, Akdis, CA (2012) IgE class switching and cellular memory. Nat Immunol 13: pp. 312-314
197. Talay, O, Yan, D, Brightbill, HD, Straney, EE, Zhou, M, Ladi, E, Lee, WP, Egen, JG, Austin, CD, Xu, M, Wu, LC (2012) IgE(+) memory B cells and plasma cells generated through a germinal-center pathway. Nat Immunol 13: pp. 396-404
198. Akdis, CA, Bachert, C, Cingi, C, Dykewicz, MS, Hellings, PW, Naclerio, RM, Schleimer, RP, Ledford, D (2013) Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol 131: pp. 1479-1490
199. Kilty, SJ, Desrosiers, MY (2009) Are biofilms the answer in the pathophysiology and treatment of chronic rhinosinusitis?. Immunol Allergy Clin North Am 29: pp. 645-656
200. Lanza, DC, Kennedy, DW (1997) Adult rhinosinusitis defined. Otolaryngol Head Neck Surg 117: pp. S1-S7
201. Brook, I, Yocum, P, Frazier, EH (1996) Bacteriology and beta-lactamase activity in acute and chronic maxillary sinusitis. Arch Otolaryngol Head Neck Surg 122: pp. 418-423
202. Bhattacharyya, N, Kepnes, LJ (1999) The microbiology of recurrent rhinosinusitis after endoscopic sinus surgery. Arch Otolaryngol Head Neck Surg 125: pp. 1117-1120
203. Bhattacharyya, N (2002) The role of infection in chronic rhinosinusitis. Curr Allergy Asthma Rep 2: pp. 500-506
204. Huvenne, W, Hellings, PW, Bachert, C (2008) Role of staphylococcal superantigens in upper airway disease. Curr Opin Allergy Clin Immunol 8: pp. 34-38
205. Suh, JD, Cohen, NA, Palmer, JN (2010) Biofilms in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 18: pp. 27-31
206. Suh, JD, Ramakrishnan, V, Palmer, JN (2010) Biofilms. Otolaryngol Clin North Am 43: pp. 521-530
207. Lewis, K (2007) Persister cells, dormancy and infectious disease. Nat Rev Microbiol 5: pp. 48-56
208. Palmer, JN (2005) Bacterial biofilms: Do they play a role in chronic sinusitis?. Otolaryngol Clin North Am 38: pp. 1193-1201
209. Al-Mutairi, D, Kilty, SJ (2011) Bacterial biofilms and the pathophysiology of chronic rhinosinusitis. Curr Opin Allergy Clin Immunol 11: pp. 18-23
210. Sanderson, AR, Leid, JG, Hunsaker, D (2006) Bacterial biofilms on the sinus mucosa of human subjects with chronic rhinosinusitis. Laryngoscope 116: pp. 1121-1126
211. Prince, AA, Steiger, JD, Khalid, AN, Dogrhamji, L, Reger, C, Eau Claire, S, Chiu, AG, Kennedy, DW, Palmer, JN, Cohen, NA (2008) Prevalence of biofilm-forming bacteria in chronic rhinosinusitis. Am J Rhinol 22: pp. 239-245
212. Foreman, A, Psaltis, AJ, Tan, LW, Wormald, PJ (2009) Characterization of bacterial and fungal biofilms in chronic rhinosinusitis. Am J Rhinol Allergy 23: pp. 556-561
213. Singhal, D, Foreman, A, Bardy, JJ, Wormald, PJ (2011) Staphylococcus aureus biofilms: Nemesis of endoscopic sinus surgery. Laryngoscope 121: pp. 1578-1583
214. Foreman, A, Holtappels, G, Psaltis, AJ, Jervis-Bardy, J, Field, J, Wormald, PJ, Bachert, C (2011) Adaptive immune responses in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Allergy 66: pp. 1449-1456
215. Wood, AJ, Fraser, J, Swift, S, Amirapu, S, Douglas, RG (2011) Are biofilms associated with an inflammatory response in chronic rhinosinusitis?. Int Forum Allergy Rhinol 1: pp. 335-339
216. Foreman, A, Jervis-Bardy, J, Wormald, PJ (2011) Do biofilms contribute to the initiation and recalcitrance of chronic rhinosinusitis?. Laryngoscope 121: pp. 1085-1091
217. Ebbens, FA, Georgalas, C, Fokkens, WJ (2009) Fungus as the cause of chronic rhinosinusitis: the case remains unproven. Curr Opin Otolaryngol Head Neck Surg 17: pp. 43-49
218. Ebbens, FA, Georgalas, C, Fokkens, WJ (2009) The mold conundrum in chronic hyperplastic sinusitis. Curr Allergy Asthma Rep 9: pp. 114-120
219. Ponikau, JU, Sherris, DA, Kern, EB, Homburger, HA, Frigas, E, Gaffey, TA, Roberts, GD (1999) The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 74: pp. 877-884
220. Braun, H, Buzina, W, Freudenschuss, K, Beham, A, Stammberger, H (2003) 'Eosinophilic fungal rhinosinusitis': A common disorder in Europe?. Laryngoscope 113: pp. 264-269
221. Sasama, J, Sherris, DA, Shin, SH, Kephart, GM, Kern, EB, Ponikau, JU (2005) New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 13: pp. 2-8
222. Davis, LJ, Kita, H (2004) Pathogenesis of chronic rhinosinusitis: role of airborne fungi and bacteria. Immunol Allergy Clin North Am 24: pp. 59-73
223. Ponikau, JU, Sherris, DA, Kephart, GM, Kern, EB, Congdon, DJ, Adolphson, CR, Springett, MJ, Gleich, GJ, Kita, H (2005) Striking deposition of toxic eosinophil major basic protein in mucus: Implications for chronic rhinosinusitis. J Allergy Clin Immunol 116: pp. 362-369
224. Shin, SH, Ponikau, JU, Sherris, DA, Congdon, D, Frigas, E, Homburger, HA, Swanson, MC, Gleich, GJ, Kita, H (2004) Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol 114: pp. 1369-1375
225. Wei, JL, Kita, H, Sherris, DA, Kern, EB, Weaver, A, Ponikau, JU (2003) The chemotactic behavior of eosinophils in patients with chronic rhinosinusitis. Laryngoscope 113: pp. 303-306
226. Inoue, Y, Matsuwaki, Y, Shin, SH, Ponikau, JU, Kita, H (2005) Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils. J Immunol 175: pp. 5439-5447
227. Romani, L (2011) Immunity to fungal infections. Nat Rev Immunol 11: pp. 275-288
228. Douglas, R, Bruhn, M, Tan, LW, Ooi, E, Psaltis, A, Wormald, PJ (2007) Response of peripheral blood lymphocytes to fungal extracts and staphylococcal superantigen B in chronic rhinosinusitis. Laryngoscope 117: pp. 411-414
229. Orlandi, RR, Marple, BF, Georgelas, A, Durtschi, D, Barr, L (2009) Immunologic response to fungus is not universally associated with rhinosinusitis. Otolaryngol Head Neck Surg 141: pp. 750-756
230. Ponikau, JU, Sherris, DA, Kita, H, Kern, EB (2002) Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol 110: pp. 862-866
231. Ponikau, JU, Sherris, DA, Weaver, A, Kita, H (2005) Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol 115: pp. 125-131
232. Weschta, M, Rimek, D, Formanek, M, Polzehl, D, Podbielski, A, Riechelmann, H (2004) Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 113: pp. 1122-1128
233. Liang, KL, Su, MC, Shiao, JY, Tseng, HC, Hsin, CH, Lin, JF, Jiang, RS (2008) Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. Am J Rhinol 22: pp. 52-58
234. Ebbens, FA, Scadding, GK, Badia, L, Hellings, PW, Jorissen, M, Mullol, J, Cardesin, A, Bachert, C, van Zele, TP, Dijkgraaf, MG, Lund, V, Fokkens, WJ (2006) Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 118: pp. 1149-1156
235. Ebbens, FA, Georgalas, C, Luiten, S, Van Drunen, CM, Badia, L, Scadding, GK, Hellings, PW, Jorissen, M, Mullol, J, Cardesin, A, Bachert, C, van Zele, TP, Lund, VJ, Fokkens, WJ (2009) The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. Laryngoscope 119: pp. 401-408
236. Isaacs, S, Fakhri, S, Luong, A, Citardi, MJ (2011) A meta-analysis of topical amphotericin B for the treatment of chronic rhinosinusitis. Int Forum Allergy Rhinol 1: pp. 250-254
A framework for human microbiome research. Nature 486: pp. 215-222
237. Paju, S, Bernstein, JM, Haase, EM, Scannapieco, FA (2003) Molecular analysis of bacterial flora associated with chronically inflamed maxillary sinuses. J Med Microbiol 52: pp. 591-597
238. Stephenson, MF, Mfuna, L, Dowd, SE, Wolcott, RD, Barbeau, J, Poisson, M, James, G, Desrosiers, M (2010) Molecular characterization of the polymicrobial flora in chronic rhinosinusitis. J Otolaryngol Head Neck Surg 39: pp. 182-187
239. Lewenza, S, Charron-Mazenod, L, Cho, JJ, Mechor, B (2010) Identification of bacterial contaminants in sinus irrigation bottles from chronic rhinosinusitis patients. J Otolaryngol Head Neck Surg 39: pp. 458-463
240. Feazel, LM, Robertson, CE, Ramakrishnan, VR, Frank, DN (2012) Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis. Laryngoscope 122: pp. 467-472
241. Lobid, I, Ben铆tez, P, Cardel煤s, S, De Borja Callejas, F, Lehrer-Coriat, E, Pujols, L, Picado, C, Mullol, J (2014) Oral plus nasal corticosteroids improve smell, nasal congestion, and inflammation in sino-nasal polyposis. Laryngoscope 124: pp. 50-56
242. Benninger, MS, Ferguson, BJ, Hadley, JA, Hamilos, DL, Jacobs, M, Kennedy, DW, Lanza, DC, Marple, BF, Osguthorpe, JD, Stankiewicz, JA, Anon, J, Denneny, J, Emanuel, I, Levine, H (2003) Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg 129: pp. S1-S32
243. Meltzer, EO, Hamilos, DL (2011) Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines. Mayo Clin Proc 86: pp. 427-443
244. Scadding, G, Hellings, P, Alobid, I, Bachert, C, Fokkens, W, Van Wijk, RG, Gevaert, P, Guilemany, J, Kalogjera, L, Lund, V, Mullol, J, Passalacqua, G, Toskala, E, Van Drunen, C (2011) Diagnostic tools in Rhinology EAACI position paper. Clin Transl Allergy 1: pp. 2
245. Zacharisen, M, Casper, R (2005) Pediatric sinusitis. Immunol Allergy Clin North Am 25: pp. 313-332
246. Chan, KH, Abzug, MJ, Coffinet, L, Simoes, EA, Cool, C, Liu, AH (2004) Chronic rhinosinusitis in young children differs from adults: a histopathology study. J Pediatr 144: pp. 206-212
247. Berger, G, Kogan, T, Paker, M, Berger-Achituv, S, Ebner, Y (2011) Pediatric chronic rhinosinusitis histopathology: differences and similarities with the adult form. Otolaryngol Head Neck Surg 144: pp. 85-90
248. Zuliani, G, Carron, M, Gurrola, J, Coleman, C, Haupert, M, Berk, R, Coticchia, J (2006) Identification of adenoid biofilms in chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol 70: pp. 1613-1617
249. Brook, I, Yocum, P, Shah, K (2000) Aerobic and anaerobic bacteriology of concurrent chronic otitis media with effusion and chronic sinusitis in children. Arch Otolaryngol Head Neck Surg 126: pp. 174-176
250. Brook, I, Frazier, EH (2004) Microbiology of recurrent acute rhinosinusitis. Laryngoscope 114: pp. 129-131
251. Dykewicz, MS, Hamilos, DL (2010) Rhinitis and sinusitis. J Allergy Clin Immunol 125: pp. S103-S115
252. Wald, ER Sinusitis. In: Long, S, Pickering, L, Prober, C eds. (2003) Principles and practice of pediatric infectious disease. Churchill Livingstone, New York, pp. 205-210
253. Clinical practice guideline: management of sinusitis / Pediatrics 2001, 108:798鈥?08.
254. DeMuri, GP, Wald, ER (2010) Acute sinusitis: clinical manifestations and treatment approaches. Pediatr Ann 39: pp. 34-40
255. Ungkanont, K, Damrongsak, S (2004) Effect of adenoidectomy in children with complex problems of rhinosinusitis and associated diseases. Int J Pediatr Otorhinolaryngol 68: pp. 447-451
256. Brietzke, SE, Brigger, MT (2008) Adenoidectomy outcomes in pediatric rhinosinusitis: a meta-analysis. Int J Pediatr Otorhinolaryngol 72: pp. 1541-1545
257. Duse, M, Caminiti, S, Zicari, AM (2007) Rhinosinusitis: prevention strategies. Pediatr Allergy Immunol 18: pp. 71-74
258. Whitney, CG, Farley, MM, Hadler, J, Harrison, LH, Bennett, NM, Lynfield, R, Reingold, A, Cieslak, PR, Pilishvili, T, Jackson, D, Facklam, RR, Jorgensen, JH, Schuchat, A (2003) Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N Engl J Med 348: pp. 1737-1746
259. Wallwork, B, Coman, W, Mackay-Sim, A, Greiff, L, Cervin, A (2006) A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope 116: pp. 189-193
260. Jirarattanasopa N, Ratanachai O, Pacharn P, Visitsunthorn N, Vichyanond P, Jirapongsananuruk O: The efficacy of azithromycin for the prevention of recurrent sinusitis in children. / J Allergy Clin Immunol 2009.,123(S202):
261. Tomassen, P, Jarvis, D, Newson, R, Van Ree, R, Forsberg, R, Howarth, P, Janson, C, Kowalski, ML, Kr盲mer, U, Matricardi, PM, Middelveld, RJM, Todo-Bom, A, Toskala, E, Thilsing, T, Bro偶ek, G, Van Drunen, C, Burney, P, Bachert, C (2013) Staphylococcus aureus enterotoxin specific IgE and its association with asthma in the general population: a GA2LEN. Allergy 68: pp. 1289-1297
262. Bachert, C, Van Steen, K, Zhang, N, Holtappels, G, Cattaert, T, Maus, B, Buhl, R, Taube, C, Korn, S, Kowalski, M, Bousquet, J, Howarth, P (2012) Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma. J Allergy Clin Immunol 130: pp. 376-381
263. Suzaki, H, Watanabe, S, Pawankar, R (2013) Rhinosinusitis and asthma-microbiome and new perspectives. Curr Opin Allergy Clin Immunol 13: pp. 45-49
264. Feng, CH, Miller, MD, Simon, RA (2012) The united allergic airway: connections between allergic rhinitis, asthma, and chronic sinusitis. Am J Rhinol Allergy 26: pp. 187-190
265. Braunstahl, GJ (2009) United airways concept: what does it teach us about systemic inflammation in airways disease?. Proc Am Thorac Soc 6: pp. 652-654
266. Bresciani, M, Paradis, L, Roches, AD, Vernhet, H, Vachier, I, Godard, P, Bousquet, J, Chanez, P (2001) Rhinosinusitis in severe asthma. J Allergy Clin Immunol 107: pp. 73-80
267. Lin, DC, Chandra, RK, Tan, BK, Zirkle, W, Conley, DB, Grammer, LC, Kern, RC, Schleimer, RP, Peters, AT (2011) Association between severity of asthma and degree of chronic rhinosinusitis. Am J Rhinol Allergy 25: pp. 205-208
268. Ten Brinke, A, Grootendorst, DC, Schmidt, JT, De Bru茂ne, FT, Van Buchem, MA, Sterk, PJ, Rabe, KF, Bel, EH (2002) Chronic sinusitis in severe asthma is related to sputum eosinophilia. J Allergy Clin Immunol 109: pp. 621-626
269. Ponikau, JU, Sherris, DA, Kephart, GM, Kern, EB, Gaffey, TA, Tarara, JE, Kita, H (2003) Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?. J Allergy Clin Immunol 112: pp. 877-882
270. Berges-Gimeno, MP, Simon, RA, Stevenson, DD (2002) The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol 89: pp. 474-478
271. Garcia Cruz, ML, Jimenez-Chobillon, MA, Teran, LM (2012) Rhinosinusitis and aspirin-exacerbated respiratory disease. J Allergy (Cairo) 2012: pp. 273752
272. Bachert, C, Claeys, SE, Tomassen, P, Van Zele, T, Zhang, N (2010) Rhinosinusitis and asthma: a link for asthma severity. Curr Allergy Asthma Rep 10: pp. 194-201
273. Stedman, RL (1968) The chemical composition of tobacco and tobacco smoke. Chem Rev 68: pp. 153-207
274. Walker, TR, Kiefer, JE (1966) Ciliastatic components in the gas phase of cigarette smoke. Science 153: pp. 1248-1250
275. Dalhamn, T, Rylander, R (1970) Ciliotoxicity of cigar and cigarette smoke. Arch Environ Health 20: pp. 252-253
276. Agius, AM, Wake, M, Pahor, AL, Smallman, A (1995) The effects of in vitro cotinine on nasal ciliary beat frequency. Clin Otolaryngol Allied Sci 20: pp. 465-469
277. Churg, A, Dai, J, Tai, H, Xie, C, Wright, JL (2002) Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am J Respir Crit Care Med 166: pp. 849-854
278. Gustafsson, A, Asman, B, Bergstr枚m, K (2000) Cigarette smoking as an aggravating factor in inflammatory tissue-destructive diseases. Increase in tumor necrosis factor-alpha priming of peripheral neutrophils measured as generation of oxygen radicals. Int J Clin Lab Res 30: pp. 187-190
279. Reh, DD, Higgins, TS, Smith, TL (2012) Impact of tobacco smoke on chronic rhinosinusitis: a review of the literature. Int Forum Allergy Rhinol 2: pp. 362-369
280. Lieu, JE, Feinstein, AR (2000) Confirmations and surprises in the association of tobacco use with sinusitis. Arch Otolaryngol Head Neck Surg 126: pp. 940-946
281. Houser, SM, Keen, KJ (2008) The role of allergy and smoking in chronic rhinosinusitis and polyposis. Laryngoscope 118: pp. 1521-1527
282. Kennedy, DW (1992) Prognostic factors, outcomes and staging in ethmoid sinus surgery. Laryngoscope 102: pp. 1-18
283. Krzeski, A, Galewicz, A, Chmielewski, R, Kisiel, M (2011) Influence of cigarette smoking on endoscopic sinus surgery long-term outcomes. Rhinology 49: pp. 577-582
284. Willes, SR, Fitzgerald, TK, Permutt, T, Proud, D, Haley, NJ, Bascom, R (1998) Acute respiratory response to prolonged, moderate levels of sidestream tobacco smoke. J Toxicol Environ Health A 53: pp. 193-209
285. Cohen, NA, Zhang, S, Sharp, DB, Tamashiro, E, Chen, B, Sorscher, EJ, Woodworth, BA (2009) Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency. Laryngoscope 119: pp. 2269-2274
286. Goldstein-Daruech, N, Cope, EK, Zhao, KQ, Vukovic, K, Kofonow, JM, Doghramji, L, Gonz谩lez, B, Chiu, AG, Kennedy, DW, Palmer, JN, Leid, JG, Kreindler, JL, Cohen, NA (2011) Tobacco smoke mediated induction of sinonasal microbial biofilms. PLoS One 6: pp. e15700
287. Yee, KK, Pribitkin, EA, Cowart, BJ, Vainius, AA, Klock, CT, Rosen, D, Hahn, CG, Rawson, NE (2009) Smoking-associated squamous metaplasia in olfactory mucosa of patients with chronic rhinosinusitis. Toxicol Pathol 37: pp. 594-598
288. Litvack, JR, Mace, JC, Smith, TL (2009) Olfactory function and disease severity in chronic rhinosinusitis. Am J Rhinol Allergy 23: pp. 139-144
289. Frye, RE, Schwartz, BS, Doty, RL (1990) Dose-related effects of cigarette smoking on olfactory function. JAMA 263: pp. 1233-1236
290. Yamin, M, Holbrook, EH, Gray, ST, Harold, R, Busaba, N, Sridhar, A, Powell, KJ, Hamilos, DL (2008) Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5 expression in chronic rhinosinusitis. J Allergy Clin Immunol 122: pp. 1145-1153
291. Misso, NL, Thompson, PJ (2005) Oxidative stress and antioxidant deficiencies in asthma: potential modification by diet. Redox Rep 10: pp. 247-255
292. Comhair, SA, Bhathena, PR, Farver, C, Thunnissen, FB, Erzurum, SC (2001) Extracellular glutathione peroxidase induction in asthmatic lings: evidence for redox regulation of expression in human airway epithelial cells. FASEB J 15: pp. 70-78
293. Xiao, C, Puddicombe, SM, Feld, S, Haywood, J, Broughton-Head, V, Puxeddu, I, Haitchi, HM, Vernon-Wilson, E, Sammut, D, Bedke, N, Cremin, C, Sones, J, Djukanovi膰, R, Howarth, PH, Collins, JE, Holgate, ST, Monk, P, Davies, DE (2011) Defective epithelial barrier function in asthma. J Allergy Clin Immunol 128: pp. 549-556
294. Lane, AP, Truong-Tran, QA, Myers, A, Bickel, C, Schleimer, RP (2006) Serum amyloid A, properdin, complement 3, and toll-like receptors are expressed locally in human sinonasal tissue. Am J Rhinol 20: pp. 117-123
295. Vandermeer, J, Sha, Q, Lane, AP, Schleimer, RP (2004) Innate immunity of the sinonasal cavity: Expression of messenger RNA for complement cascade components and toll-like receptors. Arch Otolaryngol Head Neck Surg 130: pp. 1374-1380
296. Lee, WK, Ramanathan, M, Spannhake, EW, Lane, AP (2007) The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human beta-defensin 2 by sinonasal epithelial cells. Am J Rhinol 21: pp. 658-663
297. Huvenne, W, P茅rez-Novo, CA, Derycke, L, De Ruyck, N, Krysko, O, Maes, T, Pauwels, N, Robays, L, Bracke, KR, Joos, G, Brusselle, G, Bachert, C (2010) Different regulation of cigarette smoke induced inflammation in upper versus lower airways. Respir Res 11: pp. 100
298. Rudmik, L, Mace, JC, Smith, TL (2011) Smoking and endoscopic sinus surgery: Does smoking volume contribute to clinical outcome?. Int Forum Allergy Rhinol 1: pp. 145-152
299. G贸mez, FP, Rodriquez-Roisin, R (2002) Global initiative for chronic obstructive lung disease (GOLD) guidelines for chronic obstructive pulmonary disease. Curr Opin Pulm Med 8: pp. 81-86
300. Bascom, R (1991) The upper respiratory tract: Mucous membrane irritation. Environ Health Perspect 95: pp. 39-44
301. Stanley, PJ, Wilson, R, Greenstone, MA, MacWilliam, L, Cole, PJ (1986) Effect of cigarette smoking on nasal mucociliary clearance and ciliary beat frequency. Thorax 41: pp. 519-523
302. Vachier, I, Vignola, AM, Chiappara, G, Bruno, A, Meziane, H, Godard, P, Bousquet, J, Chanez, P (2004) Inflammatory features of nasal mucosa in smokers with and without COPD. Thorax 59: pp. 303-307
303. Phillips, DE, Hill, L, Weller, P, Willett, M, Bakewell, R (2003) Tobacco smoke and the upper airway. Clin Otolaryngol Allied Sci 28: pp. 492-496
304. Hurst, JR, Wilkinson, TM, Donaldson, GC, Wedzicha, JA (2004) Upper airway symptoms and quality of life in chronic obstructive pulmonary disease (COPD). Respir Med 98: pp. 767-770
305. Hens, G, Vanaudenaerde, BM, Bullens, DM, Piessens, M, Decramer, M, Dupont, LJ, Ceuppens, JL, Hellings, PW (2008) Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy. Allergy 63: pp. 261-267
306. Hellings, PW, Hens, G (2009) Rhinosinusitis and the lower airways. Immunol Allergy Clin North Am 29: pp. 733-740
307. Guilemany, JM, Angrill, J, Alobid, I, Centellas, S, Pujols, L, Bartra, J, Bernal-Sprekelsen, M, Valero, A, Picado, C, Mullol, J (2009) United airways again: high prevalence of rhinosinusitis and nasal polyps in bronchiectasis. Allergy 64: pp. 790-797
308. Guilemany, JM, Mari帽o-S谩nchez, FS, Angrill, J, Alobid, I, Centellas, S, Pujols, L, Berenguer, J, Bernal-Sprekelsen, M, Picado, C, Mullol, J (2011) The importance of smell in patients with bronchiectasis. Respir Med 105: pp. 44-49
309. Kelemence, A, Abadoglu, O, Gumus, C, Berk, S, Epozturk, K, Akkurt, I (2011) The frequency of chronic rhinosinusitis/nasal polyp in COPD and its effect on the severity of COPD. COPD 8: pp. 8-12
310. Balzano, G, Stefanelli, F, Iorio, C, De Felice, A, Melillo, EM, Martucci, M, Melillo, G (1999) Eosinophilic inflammation in stable chronic obstructive pulmonary disease. Relationship with neutrophils and airway function. Am J Respir Crit Care Med 160: pp. 1486-1492
311. Henke, MO, Shah, SA, Rubin, BK (2005) The role of airway secretions in COPD鈥揷linical applications. COPD 2: pp. 377-390
312. Hurst, JR, Wilkinson, TM, Perera, WR, Donaldson, GC, Wedzicha, JA (2005) Relationships among bacteria, upper airway, lower airway, and systemic inflammation in COPD. Chest 127: pp. 1219-1226
313. Hurst, JR, Perera, WR, Wilkinson, TM, Donaldson, GC, Wedzicha, JA (2006) Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 173: pp. 71-78
314. Aukema, AA, Mulder, PG, Fokkens, WJ (2005) Treatment of nasal polyposis and chronic rhinosinusitis with fluticasone propionate nasal drops reduces need for sinus surgery. J Allergy Clin Immunol 115: pp. 1017-1023
315. Hissaria, P, Smith, W, Wormald, PJ, Taylor, J, Vadas, M, Gillis, D, Kette, F (2006) Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures. J Allergy Clin Immunol 118: pp. 128-133
316. Chow, AW, Benninger, MS, Brook, I, Brozek, JL, Goldstein, EJ, Hicks, LA, Pankey, GA, Seleznick, M, Volturo, G, Wald, ER, File, TM (2012) IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis 54: pp. e72-e112
317. Videler, WJ, Badia, L, Harvey, RJ, Gane, S, Georgalas, C, van der Meulen, FW, Menger, DJ, Lehtonen, MT, Toppila-Salmi, SK, Vento, SI, Hyt枚nen, M, Hellings, PW, Kalogjera, L, Lund, VJ, Scadding, G, Mullol, J, Fokkens, WJ (2011) Lack of efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial. Allergy 66: pp. 1457-1468
318. Lim, M, Citardi, MJ, Leong, JL (2008) Topical antimicrobials in the management of chronic rhinosinusitis: a systematic review. Am J Rhinol 22: pp. 381-389
319. Vaughan, WC, Carvalho, G (2002) Use of nebulized antibiotics for acute infections in chronic sinusitis. Otolaryngol Head Neck Surg 127: pp. 558-568
320. Kennedy, DW, Kuhn, FA, Hamilos, DL, Zinreich, SJ, Butler, D, Warsi, G, Pfister, PJ, Tavakkol, A (2005) Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope 115: pp. 1793-1799
321. Stewart, RA, Ram, B, Hamilton, G, Weiner, J, Kane, KJ (2008) Montelukast as an adjunct to oral and inhaled steroid therapy in chronic nasal polyposis. Otolaryngol Head Neck Surg 139: pp. 682-687
322. Parnes, SM, Chuma, AV (2000) Acute effects of antileukotrienes on sinonasal polyposis and sinusitis. ENT J 79: pp. 18-20
323. Harvey R, Hannan SA, Badia L, Scadding G: Nasal saline irrigations for the symptoms of chronic rhinosinusitis. / Cochr Database Syst Rev 2007.,18(3): CD006394
324. Lumry, WR, Curd, JG, Zeiger, RS, Pleskow, WW, Stevenson, DD (1983) Aspirin-sensitive rhinosinusitis: the clinical syndrome and effects of aspirin administration. J Allergy Clin Immunol 71: pp. 580-587
325. Schapowal, AG, Simon, HU, Schmitz-Schumann, M (1995) Phenomenology, pathogenesis, diagnosis and treatment of aspirin-sensitive rhinosinusitis. Acta Oto-rhino-laryngol Belgica 49: pp. 235-250
326. Gosepath, J, Schaefer, D, Amedee, RG, Mann, WJ (2001) Individual monitoring of aspirin desensitization. Arch Otolaryngol Head Neck Surg 127: pp. 316-321
327. Lee, JY, Simon, RA, Stevenson, DD (2007) Selection of aspirin dosages for aspirin desensitization treatment in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol 119: pp. 157-164
328. Rozsasi, A, Polzehl, D, Deutschle, T, Smith, E, Wiesmiller, K, Riechelmann, H, Keck, T (2008) Long-term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300 mg aspirin daily. Allergy 63: pp. 1228-1234
329. Messerklinger, W (1978) Endoscopy of the nose. Urban and Schwarzenberg, Baltimore
330. Zinreich, SJ, Kennedy, DW, Rosenbaum, AE, Gayler, BW, Kumar, AJ, Stammberger, H (1987) Paranasal sinuses: CT imaging requirements for endoscopic surgery. Radiology 163: pp. 769-775
331. Welch, KC, Stankiewicz, JA (2009) A contemporary review of endoscopic sinus surgery: techniques, tools, and outcomes. Laryngoscope 119: pp. 2258-2268
332. Cohen, NA, Kennedy, DW (2005) Endoscopic sinus surgery: where we are-and where we're going. Curr Opin Otolaryngol Head Neck Surg 13: pp. 32-38
333. Stammberger, H (1986) Endoscopic endonasal surgery--concepts in treatment of recurring rhinosinusitis. Part I. Anatomic and pathophysiologic considerations. Otolaryngol Head Neck Surg 94: pp. 143-147
334. Kennedy, DW, Zinreich, SJ, Rosenbaum, AE, Johns, ME (1985) Functional endoscopic sinus surgery. Theory and diagnostic evaluation. Arch Otolaryngol 111: pp. 576-582
335. Kennedy, DW, Kennedy, DW, Bolger, WE, Zinreich, SJ (2001) Functional endoscopic sinus surgery: Concepts, surgical indications, and instrumentation, in Diseases of the sinuses: Diagnosis and management. B.B.Decker Inc, Hamilton, London
336. Govindaraj, S, Adappa, ND, Kennedy, DW (2010) Endoscopic sinus surgery: evolution and technical innovations. J Laryngol Otol 124: pp. 242-250
337. Reilly, JS (1990) The sinusitis cycle. Otolaryngol Head Neck Surg 103: pp. 856-861
338. Chiu, AG, Kennedy, DW (2004) Disadvantages of minimal techniques for surgical management of chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 12: pp. 38-42
339. Khalil HS, Nunez DA: Functional endoscopic sinus surgery for chronic rhinosinusitis. / Cochr Database Syst Rev 2006.,19(3): CD004458
340. Smith, TL, Kern, R, Palmer, JN, Schlosser, R, Chandra, RK, Chiu, AG, Conley, D, Mace, JC, Fu, RF, Stankiewicz, J (2013) Medical therapy vs surgery for chronic rhinosinusitis: a prospective, multi-institutional study with 1-year follow-up. Int Forum Allergy Rhinol 3: pp. 4-9
341. Smith, TL, Batra, PS, Seiden, AM, Hannley, M (2005) Evidence supporting endoscopic sinus surgery in the management of adult chronic rhinosinusitis: a systematic review. Am J Rhinol 19: pp. 537-543
342. Dalziel, K, Stein, K, Round, A, Garside, R, Royle, P (2006) Endoscopic sinus surgery for the excision of nasal polyps: A systematic review of safety and effectiveness. Am J Rhinol 20: pp. 506-519
343. Chester, AC, Antisdel, JL, Sindwani, R (2009) Symptom-specific outcomes of endoscopic sinus surgery: a systematic review. Otolaryngol Head Neck Surg 140: pp. 633-639
344. Hopkins, C, Slack, R, Lund, V, Brown, P, Copley, L, Browne, J (2009) Long-term outcomes from the English national comparative audit of surgery for nasal polyposis and chronic rhinosinusitis. Laryngoscope 119: pp. 2459-2465
345. Penn, R, Mikula, S (2007) The role of anti-IgE immunoglobulin therapy in nasal polyposis: a pilot study. Am J Rhinol 21: pp. 428-432
346. Vennera, MC, Picado, C, Mullol, J, Alobid, I, Bernal-Sprekelsen, M (2011) Efficacy of omalizumab in the treatment of nasal polyps. Thorax 66: pp. 824-825
347. Pinto, JM, Mehta, N, Di Tineo, M, Wang, J, Baroody, FM, Naclerio, RM (2010) A randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitis. Rhinology 48: pp. 318-324
348. Gevaert, P, Lang-Loidolt, D, Lackner, A, Stammberger, H, Staudinger, H, Van Zele, T, Holtappels, G, Tavernier, J, Van Cauwenberge, P, Bachert, C (2006) Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol 118: pp. 1133-1141
349. Gevaert, P, Van Bruaene, N, Cattaert, T, Van Steen, K, Van Zele, T, Acke, F, De Ruyck, N, Blomme, K, Sousa, AR, Marshall, RP, Bachert, C (2011) Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol 128: pp. 989-95.e1-8
350. Simon, HU, Yousefi, S, Schranz, C, Schapowal, A, Bachert, C, Blaser, K (1997) Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 158: pp. 3902-3908 - 刊物主题：Allergology;
- 出版者：BioMed Central
- ISSN：1939-4551
文摘
Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-economic impact. Moreover, the complexity of this disease due to its heterogeneous nature based on the underlying pathophysiology - leading to different disease variants - further complicates our understanding and directions for the most appropriate targeted treatment strategies. Several International/national guidelines/position papers and/or consensus documents are available that present the current knowledge and treatment strategies for CRS. Yet there are many challenges to the management of CRS especially in the case of the more severe and refractory forms of disease. Therefore, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), a collaboration between EAACI, AAAAI, ACAAI, and WAO, has decided to propose an International Consensus (ICON) on Chronic Rhinosinusitis. The purpose of this ICON on CRS is to highlight the key common messages from the existing guidelines, the differences in recommendations as well as the gaps in our current knowledge of CRS, thus providing a concise reference. In this document we discuss the definition of the disease, its relevance, pharmacoeconomics, pathophysiology, phenotypes and endotypes, genetics and risk factors, natural history and co-morbidities as well as clinical manifestations and treatment options in both adults and children comprising pharmacotherapy, surgical interventions and more recent biological approaches. Finally, we have also highlighted the unmet needs that wait to be addressed through future research.