Biological potential of pyrimidine derivatives in a new era

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• 作者：Jyoti Rani ; Sanjiv Kumar ; Monika Saini ; Jyoti Mundlia…
• 刊名：Research on Chemical Intermediates
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：42
• 期：9
• 页码：6777-6804
• 全文大小：1,497 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675
• 卷排序：42

文摘

Pyrimidine and its derivatives play a wide role in drug discovery processes and have considerable chemical significance and biological activities. Pyrimidines are the building blocks of many natural compounds such as vitamins, liposacharides, and antibiotics. Pyrimidine is used as parent substance for the synthesis of a wide variety of heterocyclic compounds and raw material for drug synthesis and is also crucial in the theoretical development of heterocyclic chemistry and in organic synthesis. Pyrimidine derivatives are vital in several biological activities, i.e. antihypertensive, anticancer, antimicrobial, anti-inflammatory, and antioxidant activity. This creates interest among researchers who have synthesized a variety of pyrimidine derivatives.KeywordsPyrimidine derivativesAntihypertensiveAnticancerAntioxidantAntimicrobialAnti-inflammatory activity