Anti-cell adhesion characteristics of nanotextured surface for implantable biomedical device
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- 作者：Eui Don Han ; Byeong Hee Kim ; Young Ho Seo
- 关键词：Anti ; cell adhesion ; Nanotextured surface ; Biocompatible polymer ; Implantable medical device
- 刊名：International Journal of Precision Engineering and Manufacturing
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：18
- 期：2
- 页码：239-244
- 全文大小：
- 刊物类别：Engineering
- 刊物主题：Industrial and Production Engineering; Materials Science, general;
- 出版者：Korean Society for Precision Engineering
- ISSN：2005-4602
- 卷排序：18
文摘
In this study, anti-cell adhesion characteristics of a nanotextured polymer surface prepared by a nano-imprint process were investigated by culturing NIH 3T3 fibroblast cells on the surface. The nanotextured surface, made of biocompatible polymer, was covered by nanodimples having a diameter of 220± 5 nm and inter-hole distance of 320 ± 5 nm. Migration of NIH 3T3 cells was confined within a small area, and cell aggregation was observed on the nanotextured surface. Aggregated cells were fully viable. On the other hand, NIH 3T3 cells cultured on a smooth surface actively migrated and eventually covered the entire surface area after 56 hours. Because the nanotextured surface displayed anti-cell adhesion characteristics without causing apoptosis, it can be used in implantable biomedical devices to confer anti-cell adhesion properties without any chemical treatment.