Sex differences in the aging pattern of renin–angiotensin system serum peptidases

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• 作者：A. Fernández-Atucha ; A. Izagirre ; A. B. Fraile-Bermúdez…
• 关键词：Sex differences ; Renin–angiotensin system ; Serum peptidases ; Aging
• 刊名：Biology of Sex Differences
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：8
• 期：1
• 全文大小：403KB
• 刊物主题：Human Physiology; Endocrinology;
• 出版者：BioMed Central
• ISSN：2042-6410
• 卷排序：8

文摘

BackgroundSerum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin–angiotensin system (RAS). Dysregulation of these enzymes has been associated with hypertension and cardiovascular risk. In the present study, serum activities of RAS peptidases were analyzed to evaluate the existence of sexual differences, with a possible different pattern in pre- and post-andropausal/post-menopausal participants.