Postoperative C-reactive protein measurement predicts the severity of complications following surgery for colorectal cancer

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• 作者：Stephen T. McSorley ; Michelle L. Ramanathan…
• 关键词：Colorectal cancer ; C ; reactive protein ; Postoperative complication ; Clavien ; Dindo
• 刊名：International Journal of Colorectal Disease
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：30
• 期：7
• 页码：913-917
• 全文大小：217 KB
• 参考文献：1.Cancer Stats, Cancer Research UK. (2014) http://?www.?cancerresearchuk-?org/?cancer-info/?cancerstats/?incidence/?commoncancers/-/span> . Accessed 19 Jan 2015
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• 作者单位：Stephen T. McSorley (1)
  Michelle L. Ramanathan (1)
  Paul G. Horgan (1)
  Donald C. McMillan (1)
  
  1. Academic Unit of Surgery, School of Medicine, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G4 0SF, UK
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Internal Medicine
  Gastroenterology
  Hepatology
  Proctology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1262

文摘

Purpose Studies have shown that postoperative serum C-reactive protein (CRP) measurement may be useful in predicting the type of complication, infective or otherwise, following surgery for colorectal cancer. It may be that the magnitude of the postoperative CRP is also associated with the severity of the complication. The aim of the present study was to examine the relationship between daily postoperative CRP concentrations and Clavien-Dindo complication grade. Patients and methods Data was recorded prospectively for patients undergoing elective, potentially curative, surgery for colorectal cancer in two hospitals between January 2011 and January 2013, n--41. All patients had daily CRP measurement following surgery for the first four postoperative days. Complications were retrospectively classified by Clavien-Dindo grade. Results Of the 241 patients, the majority were male (59?%) and were over 65?years old (69?%). The majority had colonic (86?%) and node negative (65?%) disease. One hundred nineteen patients (49?%) developed a complication, and 28 (12?%) of these were Clavien-Dindo grade 3, 4 or 5. Median and established threshold CRP concentrations on postoperative days 2 (>190?mg/L), 3 (>170?mg/L) and 4 (>125?mg/L) were directly associated with an increase in the Clavien-Dindo grade (all p-lt;-.001). Conclusion There was a direct association between exceeding established postoperative day 2, 3 and 4 CRP thresholds and the severity of complications defined by the Clavien-Dindo grade.