Thermo-mechanical analysis of soft tissue in local hyperthermia treatment

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• 作者：Mohammad Mahdi Attar ; Mohammad Haghpanahi…
• 关键词：Hyperthermia ; Healthy and cancerous tissues ; Viscoelastic behavior ; Stress and displacement fields ; Magnetic nanoparticles
• 刊名：Journal of Mechanical Science and Technology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：30
• 期：3
• 页码：1459-1469
• 全文大小：1,858 KB
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• 作者单位：Mohammad Mahdi Attar (1)
  Mohammad Haghpanahi (2)
  Hossein Shahverdi (3)
  Ali Imam (1)
  
  1. Department of Mechanical and Aerospace Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. Department of Mechanics, Iran University of Science and Technology, Tehran, Iran
  3. Aerospace Engineering Department & Center of Excellence in Computational Aerospace, Amir Kabir University of Technology, Tehran, 15875-4413, Iran
  
• 刊物类别：Engineering
• 刊物主题：Mechanical Engineering
  Structural Mechanics
  Control Engineering
  Industrial and Production Engineering
  
• 出版者：The Korean Society of Mechanical Engineers
• ISSN：1976-3824

文摘

Magnetic fluid hyperthermia is a new subclass of hyperthermia cancer treatment that can selectively heat up a tumor without damaging the surrounding healthy tissues. Some authors studied the temperature distribution of a magnetically mediated tumor assuming a homogeneous distribution of nanoparticles inside the tumor. Viscoelastic behavior of cancerous and healthy tissues have been studied in various articles and many methods have been introduced for computation of physical-mechanical properties of the tissue considering the fact that thermo-mechanical properties of the tissue completely change when the tissue becomes cancerous. Purpose of this study is to investigate thermo-visco-elastic behavior of tumorous and healthy bovine liver tissue. Therefore, the tumor is simulated as a solid sphere having radius denoted as r along with the surrounding healthy tissue. Any discontinuity between cancerous and healthy tissues is neglected. Since the resulting constitutive equations are highly complex, the stress and displacement fields were calculated by using finite difference method. An experimental test was designed to validate numerical results. Numerical results are found to be in good agreement with experimental data and with other references on homogeneous dispersion of nanoparticles.