Fe3O4/salicylic acid nanoparticles versatility in magnetic mediated vascular nanoblockage

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• 作者：I. Mîndrilă ; S. A. Buteică ; D. E. Mihaiescu ; G. Badea…
• 关键词：Magnetic nanoparticles ; Salicylic acid ; CAM assay ; Magnetic targeting ; Nanoblocking ; Nanomedicine
• 刊名：Journal of Nanoparticle Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：18
• 期：1
• 全文大小：1,931 KB
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• 作者单位：I. Mîndrilă (1)
  S. A. Buteică (2)
  D. E. Mihaiescu (3)
  G. Badea (3)
  A. Fudulu (3)
  D. N. Mărgăritescu (1)
  
  1. Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares St 2, 200349, Craiova, Romania
  2. Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares St 2, 200349, Craiova, Romania
  3. Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Polizu St. 1-7, 011061, Bucharest, Romania
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nanotechnology
  Inorganic Chemistry
  Characterization and Evaluation Materials
  Physical Chemistry
  Applied Optics, Optoelectronics and Optical Devices
  
• 出版者：Springer Netherlands
• ISSN：1572-896X

文摘

An aqueous dispersion of Fe₃O₄/salicylic acid magnetic nanoparticles (SaMNPs) was synthesized by a modified Massart method, characterized by Inductively Coupled Plasma–Optic Emission Spectrometry (ICP-OES), High-Resolution Transmission Electron Microscopy (HRTEM) and Dynamic Light Scattering (DLS) methods, and tested on the chick chorioallantoic membrane (CAM) model to evaluate biocompatibility, biodistribution, intravascular time persistence, and ability to be magnetically target driven in order to block the blood supply into a tumor xenograft. ICP-OES, DLS, and HRTEM SaMNPs sample analyses showed a 0.356 mg/mL Fe concentration, a good stability in water (average Zeta potential of 39.3 mV), a hydrodynamic diameter around 52 nm and a core diameter in the 7–15 nm range for the Fe₃O₄ nanoparticles. In vivo CAM assay showed that SaMNPs were biocompatible with the chick embryo, were fixed almost completely by the liver, had no embolic potential, and a threshold-dose-dependent intravascular magnetic targeting time. Study on the CAM tumor model showed that SaMNPs could be used for long-term magnetically mediated nanoblocking of the capillary networks and 70-µm smaller arterioles.