Pathologic changes of Achilles tendon in leptin-deficient mice

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• 作者：Jinfei Ji (1) (2)
  Zuyu wang (1) (2)
  Dongquan Shi (1) (2)
  Xiang Gao (3)
  Qing Jiang (1) (2)
  
• 关键词：Diabetes mellitus ; Achilles tendon ; Pathology ; Leptin ; deficient mice
• 刊名：Rheumatology International
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：30
• 期：4
• 页码：489-493
• 全文大小：287KB
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• 作者单位：Jinfei Ji (1) (2)
  Zuyu wang (1) (2)
  Dongquan Shi (1) (2)
  Xiang Gao (3)
  Qing Jiang (1) (2)
  
  1. The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Zhongshan Road 321, 210008, Nanjing, Jiangsu, China
  2. Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, 210008, Nanjing, Jiangsu, China
  3. Model Animal Research Center (MARC) of Nanjing University, 210008, Nanjing, Jiangsu, China
  

文摘

The objective of this study is to explore whether diabetes play roles on histopathological change of Achilles tendon in leptin-deficient mice. Ob mice (specific-pathogen free SPF) were identified at 10?days after birth and killed via dislocation of cervical spine at 12?weeks. Achilles tendon was isolated as quickly as possible and histopathological changes were investigated. Degeneration of tendinocytes, vascular proliferation, chondrocyte-like tendon cell and ruptures at insertion areas were observed. We conclude that diabetes is associated with histopathologic change in Achilles tendon of ob mice.