Excited States in DNA Strands Investigated by Ultrafast Laser Spectroscopy

详细信息    查看全文

• 作者：Jinquan Chen (18) (19)
  Yuyuan Zhang (18)
  Bern Kohler (18)
  
• 关键词：Base pairing ; Base stacking ; Charge transfer state ; DNA photophysics ; Excimer ; Excited ; state dynamics ; Exciton ; Femtosecond transient absorption ; Proton ; coupled electron transfer
• 刊名：Topics in Current Chemistry
• 出版年：2015
• 出版时间：2015
• 年：2015
• 卷：356
• 期：1
• 页码：39-87
• 全文大小：1,712 KB
• 参考文献：1. Kohler B (2010) J Phys Chem Lett 1:2047
  2. Gustavsson T, Improta R, Markovitsi D (2010) J Phys Chem Lett 1:2025
  3. Crespo-Hernández CE, Cohen B, Hare PM, Kohler B (2004) Chem Rev 104:1977
  4. Middleton CT, de La Harpe K, Su C, Law YK, Crespo-Hernández CE, Kohler B (2009) Annu Rev Phys Chem 60:217
  5. Kleinermanns K, Nachtigallova D, de Vries MS (2013) Int Rev Phys Chem 32:308
  6. Takaya T, Su C, de La Harpe K, Crespo-Hernández CE, Kohler B (2008) Proc Natl Acad Sci USA 105:10285
  7. Schreier WJ, Schrader TE, Koller FO, Gilch P, Crespo-Hernández CE, Swaminathan VN, Carell T, Zinth W, Kohler B (2007) Science 315:625
  8. Schreier WJ, Kubon J, Regner N, Haiser K, Schrader TE, Zinth W, Clivio P, Gilch P (2009) J Am Chem Soc 131:5038
  9. Su C, Middleton CT, Kohler B (2012) J Phys Chem B 116:10266
  10. Ward DC, Reich E, Stryer L (1969) J Biol Chem 244:1228
  11. Rist MJ, Marino JP (2002) Curr Org Chem 6:775
  12. Thompson KC, Miyake N (2005) J Phys Chem B 109:6012
  13. Crespo-Hernández CE, Cohen B, Kohler B (2005) Nature 436:1141
  14. Kang H, Lee KT, Jung B, Ko YJ, Kim SK (2002) J Am Chem Soc 124:12958
  15. Ullrich S, Schultz T, Zgierski MZ, Stolow A (2004) J Am Chem Soc 126:2262
  16. Smith VR, Samoylova E, Ritze HH, Radloff W, Schultz T (2010) Phys Chem Chem Phys 12:9632
  17. Banyasz A, Vayá I, Changenet-Barret P, Gustavsson T, Douki T, Markovitsi D (2011) J Am Chem Soc 133:5163
  18. Towrie M, Grills DC, Dyer J, Weinstein JA, Matousek P, Barton R, Bailey PD, Subramaniam N, Kwok WM, Ma CS, Phillips D, Parker AW, George MW (2003) Appl Spectrosc 57:367
  19. Towrie M, Doorley GW, George MW, Parker AW, Quinn SJ, Kelly JM (2009) Analyst 134:1265
  20. Oliver TAA, Zhang Y, Ashfold MNR, Bradforth SE (2011) Faraday Discuss 150:439
  21. Zhang Y, Chen J, Kohler B (2013) J Phys Chem A 117:6771
  22. Chen J, Thazhathveetil AK, Lewis FD, Kohler B (2013) J Am Chem Soc 135:10290
  23. Kwok W-M, Ma C, Phillips DL (2006) J Am Chem Soc 128:11894
  24. Karunakaran V, Kleinermanns K, Improta R, Kovalenko SA (2009) J Am Chem Soc 131:5839
  25. Pecourt J-ML, Peon J, Kohler B (2000) J Am Chem Soc 122:9348
  26. Pecourt J-ML, Peon J, Kohler B (2001) J Am Chem Soc 123:10370
  27. Crespo-Hernández CE, Kohler B (2004) J Phys Chem B 108:11182
  28. Jou F-Y, Freeman GR (1979) J Phys Chem 83:2383
  29. Hare PM, Crespo-Hernández CE, Kohler B (2007) Proc Natl Acad Sci U S A 104:435
  30. Middleton CT, Cohen B, Kohler B (2007) J Phys Chem A 111:10460
  31. Elles CG, Rivera CA, Zhang Y, Pieniazek PA, Bradforth SE (2009) J Chem Phys 130:13
  32. Kovalenko SA, Dobryakov AL, Ruthmann J, Ernsting NP (1999) Phys Rev A 59:2369
  33. Jailaubekov AE, Bradforth SE (2005) Appl Phys Lett 87
  34. Tauber MJ, Mathies RA, Chen XY, Bradforth SE (2003) Rev Sci Instrum 74:4958
  35. Zhang Y, Improta R, Kohler B (2014) Phys Chem Chem Phys 16:1487
  36. Gustavsson T, Sharonov A, Markovitsi D (2002) Chem Phys Lett 351:195
  37. Peon J, Zewail AH (2001) Chem Phys Lett 348:255
  38. Gustavsson T, Sharonov A, Onidas D, Markovitsi D (2002) Chem Phys Lett 356:49
  39. Pancur T, Schwalb NK, Renth F, Temps F (2005) Chem Phys 313:199
  40. Markovitsi D, Gustavsson T, Talbot F (2007) Photochem Photobiol Sci 6:717
  41. Markovitsi D, Onidas D, Talbot F, Marguet S, Gustavsson T, Lazzarotto E (2006) J Photochem Photobiol. A 183:1
  42. Schweizer MP, Broom AD, Ts'o POP, Hollis DP (1968) J Am Chem Soc 90:1042
  43. Broom AD, Schweizer MP, Ts’o POP (1967) J Am Chem Soc 89:3612
  44. Valdes-Aguilera O, Neckers DC (1989) Acc Chem Res 22:171
  45. Bloomfield VA, Crothers DM, Tinoco I Jr (1974) Physical chemistry of nucleic acids. Harper & Row, New York
  46. Gray DM, Ratliff RL, Vaughan MR (1992) Methods Enzymol 211:389
  47. Woody RW (1995) Biochem Spectroscopy 246:34
  48. Berova N, Di Bari L, Pescitelli G (2007) Chem Soc Rev 36:914
  49. Kypr J, Kejnovska I, Renciuk D, Vorlickova M (2009) Nucleic Acids Res 37:1713
  50. Ke C, Humeniuk M, S-Gracz H, Marszalek PE (2007) Phys Rev Lett 99:018302
  51. Seol Y, Skinner GM, Visscher K, Buhot A, Halperin A (2007) Phys Rev Lett 98:158103
  52. Hatters DM, Wilson L, Atcliffe BW, Mulhern TD, Guzzo-Pernell N, Howlett GJ (2001) Biophys J 81:371
  53. Mills JB, Vacano E, Hagerman PJ (1999) J Mol Biol 285:245
  54. Baná? P, Mládek A, Otyepka M, Zgarbová M, Jure?ka P, Svozil D, Lanka? F, ?poner J (2012) J Chem Theory Comput 8:2448
  55. Chen AA, García AE (2013) Proc Natl Acad Sci U S A 110:16820
  56. Olson WK, Bansal M, Burley SK, Dickerson RE, Gerstein M, Harvey SC, Heinemann U, Lu X-J, Neidle S, Shakked Z, Sklenar H, Suzuki M, Tung C-S, Westhof E, Wolberger C, Berman HM (2001) J Mol Biol 313:229
  57. Rose IA, Hanson KR, Wilkinson KD, Wimmer MJ (1980) Proc Natl Acad Sci U S A 77:2439
  58. Chen J, Kohler B (2014) J Am Chem Soc 136:6362
  59. Olaso-Gon
• 作者单位：Jinquan Chen (18) (19)
  Yuyuan Zhang (18)
  Bern Kohler (18)
  
  18. Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59717, USA
  19. Department of Chemistry, Emory University, Atlanta, GA, 30322, USA
  
• ISSN：1436-5049

文摘

Ultrafast laser experiments on carefully selected DNA model compounds probe the effects of base stacking, base pairing, and structural disorder on excited electronic states formed by UV absorption in single and double DNA strands. Direct π-orbital overlap between two stacked bases in a dinucleotide or in a longer single strand creates new excited states that decay orders of magnitude more slowly than the generally subpicosecond excited states of monomeric bases. Half or more of all excited states in single strands decay in this manner. Ultrafast mid-IR transient absorption experiments reveal that the long-lived excited states in a number of model compounds are charge transfer states formed by interbase electron transfer, which subsequently decay by charge recombination. The lifetimes of the charge transfer states are surprisingly independent of how the stacked bases are oriented, but disruption of π-stacking, either by elevating temperature or by adding a denaturing co-solvent, completely eliminates this decay channel. Time-resolved emission measurements support the conclusion that these states are populated very rapidly from initial excitons. These experiments also reveal the existence of populations of emissive excited states that decay on the nanosecond time scale. The quantum yield of these states is very small for UVB/UVC excitation, but increases at UVA wavelengths. In double strands, hydrogen bonding between bases perturbs, but does not quench, the long-lived excited states. Kinetic isotope effects on the excited-state dynamics suggest that intrastrand electron transfer may couple to interstrand proton transfer. By revealing how structure and non-covalent interactions affect excited-state dynamics, on-going experimental and theoretical studies of excited states in DNA strands can advance understanding of fundamental photophysics in other nanoscale systems.