Chronic Toxic Metal Exposure and Cardiovascular Disease: Mechanisms of Risk and Emerging Role of Chelation Therapy

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• 作者：Ehimen C. Aneni ; Esteban Escolar ; Gervasio A. Lamas
• 关键词：Edetate disodium ; Chelation ; Myocardial infarction ; Lead toxicity ; Trial to Assess Chelation Therapy
• 刊名：Current Atherosclerosis Reports
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：12
• 全文大小：556 KB
• 刊物主题：Angiology; Cardiology;
• 出版者：Springer US
• ISSN：1534-6242
• 卷排序：18

文摘

Over the last few decades, there has been a growing body of epidemiologic evidence linking chronic toxic metal exposure to cardiovascular disease-related morbidity and mortality. The recent and unexpectedly positive findings from a randomized, double-blind, multicenter trial of metal chelation for the secondary prevention of atherosclerotic cardiovascular disease (Trial to Assess Chelation Therapy (TACT)) have focused the discussion on the role of chronic exposure to toxic metals in the development and propagation of cardiovascular disease and the role of toxic metal chelation therapy in the secondary prevention of cardiovascular disease. This review summarizes the most recent evidence linking chronic toxic metal exposure to cardiovascular disease and examines the findings of TACT.