Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

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• 作者：Asger Reinstrup Bihlet ; Morten Asser Karsdal…
• 关键词：COPD ; Emphysema ; Extracellular matrix ; Biomarkers ; Eosinophils
• 刊名：Respiratory Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：926KB
• 刊物主题：Pneumology/Respiratory System;
• 出版者：BioMed Central
• ISSN：1465-993X
• 卷排序：18

文摘

BackgroundChronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of the main ECM components are type I collagen, the main constituent in the interstitial matrix, type VI collagen, and elastin, the signature protein of the lungs. During pathological remodeling driven by inflammatory cells and proteases, fragments of these proteins are released into the bloodstream, where they may serve as biomarkers for disease phenotypes. The aim of this study was to investigate the lung ECM remodeling in healthy controls and COPD patients in the COPDGene study.