Effects of Glia in a Triphasic Continuum Model of Cortical Spreading Depression

详细信息    查看全文

• 作者：Rosemary O’Connell ; Yoichiro Mori
• 关键词：Cortical spreading depression ; Migraine ; Glia ; Potassium
• 刊名：Bulletin of Mathematical Biology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：78
• 期：10
• 页码：1943-1967
• 全文大小：1,090 KB
• 刊物类别：Mathematics and Statistics
• 刊物主题：Mathematics
  Mathematical Biology
  
• 出版者：Springer New York
• ISSN：1522-9602
• 卷排序：78

文摘

Cortical spreading depression (SD) is a spreading disruption in brain ionic homeostasis during which neurons experience complete and prolonged depolarizations. SD is generally believed to be the physiological substrate of migraine aura and is associated with many other brain pathologies. Here, we perform simulations with a model of SD treating brain tissue as a triphasic continuum of neurons, glia and the extracellular space. A thermodynamically consistent incorporation of the major biophysical effects, including ionic electrodiffusion and osmotic water flow, allows for the computation of important physiological variables including the extracellular voltage (DC) shift. A systematic parameter study reveals that glia can act as both a disperser and buffer of potassium in SD propagation. Furthermore, we show that the timing of the DC shift with respect to extracellular \(\hbox {K}^{+}\) rise is highly dependent on glial parameters, a result with implications for the identification of the propagating mechanism of SD.