In Vitro and In Vivo Neuronal Electrotaxis: A Potential Mechanism for Restoration?
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- 作者：Ali Jahanshahi (1) (2) (4)
Lisa-Maria Sch?nfeld (1) (3) (4)
Evi Lemmens (3) (4)
Sven Hendrix (3) (4)
Yasin Temel (1) (2) (4) - 关键词：Brain repair ; Brain stimulation ; Electrical fields ; Electrotaxis ; Regeneration
- 刊名：Molecular Neurobiology
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：49
- 期：2
- 页码：1005-1016
- 全文大小：648 KB
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Lisa-Maria Sch?nfeld (1) (3) (4)
Evi Lemmens (3) (4)
Sven Hendrix (3) (4)
Yasin Temel (1) (2) (4)
1. Department of Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands
2. Department of Neurosurgery, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, the Netherlands
4. European Graduate School of Neuroscience (EURON), Maastricht, the Netherlands
3. Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium - ISSN：1559-1182
文摘
Electrical brain stimulation used to treat a variety of neurological and psychiatric diseases is entering a new period. The technique is well established and the potential complications are well known and generally manageable. Recent studies demonstrated that electrical fields (EFs) can enhance neuroplasticity-related processes. EFs applied in the physiological range induce migration of different neural cell types from different species in vitro. There are some evidences that also the speed and directedness of cell migration are enhanced by EFs. However, it is still unclear how electrical signals from the extracellular space are translated into intracellular actions resulting in the so-called electrotaxis phenomenon. Here, we aim to provide a comprehensive review of the data on responses of cells to electrical stimulation and the relation to functional recovery.