Ventricular arrhythmias induced by long-term use of ephedrine in two competitive athletes

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• 作者：Michela Casella (1) (4)
  Antonio Dello Russo (1) (4)
  Gennaro Izzo (1) (4)
  Maurizio Pieroni (2) (4)
  Daniele Andreini (3) (4)
  Eleonora Russo (1) (4)
  Daniele Colombo (1) (4)
  Fabrizio Bologna (1) (4)
  Leonardo Bolognese (2) (4)
  Paolo Zeppilli (4) (5)
  Claudio Tondo (1) (4)
  
  1. Cardiac Arrhythmia Research Centre ; Centro Cardiologico Monzino ; IRCCS ; Via Parea ; 4 ; 20138 ; Milan ; Italy
  4. Department of Clinical Sciences and Community Health ; University of Milan ; Milan ; Italy
  2. Cardiovascular Department ; San Donato Hospital ; Arezzo ; Italy
  3. Department of Cardiovascular Imaging ; Cardiac Arrhythmia Centre Centro Cardiologico Monzino ; IRCCS ; Milan ; Italy
  5. Department of Sports Medicine ; Catholic University of the Sacred Heart ; Rome ; Italy
  
• 关键词：Ventricular arrhythmia ; Endomyocardial biopsy ; Electroanatomic mapping
• 刊名：Heart and Vessels
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：30
• 期：2
• 页码：280-283
• 全文大小：979 KB
• 参考文献：1. Abraham, J, Mudd, JO, Kapur, NK, Klein, K, Champion, HC, Wittstein, IS (2009) Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. J Am Coll Cardiol 53: pp. 1320-1325 CrossRef
  2. Dello Russo, A, Pieroni, M, Santangeli, P, Bartoletti, S, Casella, M, Pelargonio, G, Smaldone, C, Bianco, M, Biase, L, Bellocci, F, Zeppilli, P, Fiorentini, C, Natale, A, Tondo, C (2011) Concealed cardiomyopathies in competitive athletes with ventricular arrhythmias and an apparently normal heart: role of cardiac electroanatomical mapping and biopsy. Heart Rhythm 8: pp. 1915-1922 CrossRef
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  6. Franzen, E, Mangold, S, Erz, G, Claussen, CD, Niess, AM, Kramer, U, Burgstahler, C (2013) Comparison of morphological and functional adaptations of the heart in highly trained triathletes and long-distance runners using cardiac magnetic resonance imaging. Heart Vessels 28: pp. 626-631 CrossRef
  7. Li, P, Zhao, XX, Zheng, X, Qin, YW (2012) Arrhythmias after transcatheter closure of perimembranous ventricular septal defects with a modified double-disk occluder: early and long-term results. Heart Vessels 27: pp. 405-410 CrossRef
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  9. To, LB, Sangster, JF, Rampling, D, Cammens, I (1980) Ephedrine-induced cardiomyopathy. Med J Aust 2: pp. 35-36
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Cardiac Surgery
  Vascular Surgery
  Biomedical Engineering
  Interventional Radiology
  Ultrasound
  
• 出版者：Springer Japan
• ISSN：1615-2573

文摘

Ephedrine is a sympathomimetic substance used by sportsmen as a doping substance because of its stimulating and slimming effects. We report two cases of ventricular arrhythmias induced by abuse of ephedrine in two competitive athletes. Endomyocardial biopsies guided by electroanatomic mapping revealed contraction-band necrosis, a myocardial injury frequently observed in cases of catecholamine excess. Our cases suggest that long-term abuse of ephedrine may result in myocardial damage, and that these structural alterations may promote areas of slow conduction favoring re-entrant ventricular tachyarrhythmias and a long-lasting risk of ventricular arrhythmias.