MR volumetric assessment of endolymphatic hydrops

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• 作者：R. Gürkov ; A. Berman ; O. Dietrich ; W. Flatz ; C. Jerin ; E. Krause…
• 关键词：Menière’s disease ; Endolymphatic hydrops ; Magnetic resonance imaging ; Drug administration routes ; Image analysis
• 刊名：European Radiology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：25
• 期：2
• 页码：585-595
• 全文大小：2,070 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Diagnostic Radiology
  Interventional Radiology
  Neuroradiology
  Ultrasound
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1084

文摘

Objectives We aimed to volumetrically quantify endolymph and perilymph spaces of the inner ear in order to establish a methodological basis for further investigations into the pathophysiology and therapeutic monitoring of Menière’s disease. Methods Sixteen patients (eight females, aged 38-1 years) with definite unilateral Menière’s disease were included in this study. Magnetic resonance (MR) cisternography with a T2-SPACE sequence was combined with a Real reconstruction inversion recovery (Real-IR) sequence for delineation of inner ear fluid spaces. Machine learning and automated local thresholding segmentation algorithms were applied for three-dimensional (3D) reconstruction and volumetric quantification of endolymphatic hydrops. Test–retest reliability was assessed by the intra-class coefficient; correlation of cochlear endolymph volume ratio with hearing function was assessed by the Pearson correlation coefficient. Results Endolymph volume ratios could be reliably measured in all patients, with a mean (range) value of 15?% (2-5) for the cochlea and 28?% (12-0) for the vestibulum. Test-retest reliability was excellent, with an intra-class coefficient of 0.99. Cochlear endolymphatic hydrops was significantly correlated with hearing loss (r--.747, p--.001). Conclusions MR imaging after local contrast application and image processing, including machine learning and automated local thresholding, enable the volumetric quantification of endolymphatic hydrops. This allows for a quantitative assessment of the effect of therapeutic interventions on endolymphatic hydrops. Key Points -Endolymphatic hydrops is the pathological hallmark of Menière’s disease. -Endolymphatic hydrops can be visualized by locally enhanced ultra-high-resolution MR imaging. -Computer-aided image processing enables quantification of endolymphatic hydrops. -Endolymphatic hydrops correlates with hearing loss in patients with Menière’s disease. -Therapeutic trials in Menière’s disease can be monitored with this quantitative approach.