A MRS study of metabolic alterations in the frontal white matter of major depressive disorder patients with the treatment of SSRIs
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- 作者：Yifan Zhang ; Yu Han ; Yongzhi Wang ; Yinfeng Zhang ; Li Li ; Erhu Jin…
- 关键词：Antidepressant ; Magnetic resonance spectroscopy ; Major depressive disorder ; Brain metabolism
- 刊名：BMC Psychiatry
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：2,550 KB
- 刊物主题：Psychiatry; Psychotherapy;
- 出版者：BioMed Central
- ISSN：1471-244X
文摘
Background Proton magnetic resonance spectroscopy provides a non-invasive technology to study brain metabolite levels in vivo, which can be used to measure biochemical compounds or metabolite concentrations in circumscribed brain regions. Previous research has highlighted the role of glial cells in brain white matter. It has been assumed that antidepressant treatment with SSRIs not only affects neurons, but also activates glial cells. This study focused on the observation of any potential changes in the metabolite levels of the ventral prefrontal white matter in major depressive disorder (MDD) patients who have received antidepressant treatment.