Oxaliplatin activity in head and neck cancer cell lines

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• 作者：Magali Espinosa ; Moises Martinez ; Jos¨¦ Luis Aguilar ; A¨ªda Mota ; Jaime G. De la Garza ; Vilma Maldonado and Jorge Mel¨¦ndez-Zajgla
• 关键词：Oxaliplatin ; Cisplatin ; Radiation ; Resistance ; Radiosensitization
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2005
• 出版时间：March 2005
• 年：2005
• 卷：55
• 期：3
• 页码：301-305
• 全文大小：213 KB

文摘

Oxaliplatin (cis-[(1R,2R)-1,2-cyclohexanediamine-N,N] [oxalato(2-)-O,O] platinum; Eloxatin) is a third-generation platinum compound with a 1,2-diaminocyclohexane (DACH) carrier ligand, which has a wide spectrum of anticancer activity in vitro systems and has displayed preclinical and clinical activity in a wide variety of tumors. To investigate its in vitro activity against head and neck cancer, we exposed two head and neck cancer cell lines to the compound, created a variant resistant to cisplatin to study cross-resistance to the compound and analyzed the potential radiosensitizing effect of the drug. We report here that oxaliplatin was cytotoxic at similar doses to cisplatin in these cells. There was no cross-resistance to cisplatin, as demonstrated by different IC₅₀ values in these cell lines and the sensitivity to oxaliplatin of the cisplatin-resistant cell line. There was an effective radiosensitizer effect of the compound in either cell line. Additional in vitro and in vivo experimentation is warranted in order to support the use of oxaliplatin as a radiosensitizer in head and neck cancer patients.