The role of small heat shock proteins in parasites

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• 作者：Deyanira Pérez-Morales ; Bertha Espinoza
• 关键词：HSPs ; Small HSPs ; Parasites ; Stress ; Chaperone
• 刊名：Cell Stress and Chaperones
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：20
• 期：5
• 页码：767-780
• 全文大小：1,345 KB
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• 作者单位：Deyanira Pérez-Morales (1)
  Bertha Espinoza (1)
  
  1. Laboratorio de Estudios sobre Tripanosomiasis, Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, C.P. 04510, México, D.F., México
  
• 刊物主题：Biomedicine general; Cell Biology; Biochemistry, general; Immunology; Cancer Research; Neurosciences;
• 出版者：Springer Netherlands
• ISSN：1466-1268

文摘

The natural life cycle of many protozoan and helminth parasites involves exposure to several hostile environmental conditions. Under these circumstances, the parasites arouse a cellular stress response that involves the expression of heat shock proteins (HSPs). Small HSPs (sHSPs) constitute one of the main families of HSPs. The sHSPs are very divergent at the sequence level, but their secondary and tertiary structures are conserved and some of its members are related to α-crystallin from vertebrates. They are involved in a variety of cellular processes. As other HSPs, the sHSPs act as molecular chaperones; however, they have shown other activities apparently not related to chaperone action. In this review, the diverse activities of sHSPs in the major genera of protozoan and helminth parasites are described. These include stress response, development, and immune response, among others. In addition, an analysis comparing the sequences of sHSPs from some parasites using a distance analysis is presented. Because many parasites face hostile conditions through its life cycles the study of HSPs, including sHSPs, is fundamental.