The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1
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- 作者：Su-Jin Moon ; Eun-Kyung Kim ; Joo Yeon Jhun ; Hee Jin Lee…
- 关键词：Rheumatoid arthritis ; Leflunomide ; Heme oxygenase ; 1
- 刊名：Journal of Translational Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：13770KB
- 刊物主题：Biomedicine, general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1479-5876
- 卷排序：15
文摘
BackgroundLeflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, the molecular mechanism of the drug remains largely unknown. We investigated the antiarthritis effects and mechanisms of action of the active metabolite of leflunomide, A77 1726, in interleukin-1 receptor antagonist-knockout (IL-1Ra-KO) mice.