Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping
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- 作者：Nagat Frara ; Samir M. Abdelmagid ; Michael Tytell…
- 关键词：Overuse ; Osteoactivin ; Metalloproteinases ; Heat shock protein ; Restorative repair ; Muscle ; Tendon
- 刊名：BMC Musculoskeletal Disorders
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：1,739 KB
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Samir M. Abdelmagid (2)
Michael Tytell (3)
Mamta Amin (1)
Steven N. Popoff (1)
Fayez F. Safadi (4)
Mary F. Barbe (1)
1. Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA
2. Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
3. Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC, USA
4. Department of Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, USA - 刊物主题：Orthopedics; Rehabilitation; Rheumatology; Sports Medicine; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2474
文摘
Background Expression of the growth factor osteoactivin (OA) increases during tissue degeneration and regeneration, fracture repair and after denervation-induced disuse atrophy, concomitant with increased matrix metalloproteinases (MMPs). However, OA’s expression with repetitive overuse injuries is unknown. The aim of this study was to evaluate: 1) OA expression in an operant rat model of repetitive overuse; 2) expression of MMPs; 3) inflammatory cytokines indicative of injury or inflammation; and 4) the inducible form of heat shock protein 70 (HSPA1A/HSP72) as the latter is known to increase during metabolic stress and to be involved in cellular repair. Young adult female rats performed a high repetition negligible force (HRNF) food retrieval task for up to 6 weeks and were compared to control rats.